INT186507

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Context Info
Confidence 0.74
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 3.35
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ATP1A2) plasma membrane (ATP1A2) locomotion (ATP1A2)
transmembrane transport (ATP1A2) cytoplasm (ATP1A2)
Anatomy Link Frequency
neuronal 1
ATP1A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 7 100.00 Very High Very High Very High
Calcium channel 12 99.84 Very High Very High Very High
Migraine 153 98.48 Very High Very High Very High
Action potential 2 83.36 Quite High
Central nervous system 1 82.56 Quite High
sodium channel 1 81.44 Quite High
Neuronal excitability 1 80.24 Quite High
Nav1.1 1 80.16 Quite High
headache 16 77.12 Quite High
hyperexcitability 1 23.68 Low Low
Disease Link Frequency Relevance Heat
Migraine Without Aura 30 98.68 Very High Very High Very High
Migraine With Aura 61 98.56 Very High Very High Very High
Headache 127 95.80 Very High Very High Very High
Epilepsy 5 80.76 Quite High
Hemiplegia 1 80.08 Quite High
Paresis 1 79.52 Quite High
Headache Disorders 2 71.76 Quite High
Convulsion 1 61.36 Quite High
Neurological Disease 7 59.84 Quite High
Channelopathies 2 56.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since FHM2-ATP1A2 is partly a potassium channel gene and is localised nearby to the potassium channel KCNN3, it may be interesting to investigate this gene in the common forms of migraine.
Localization (localised) of FHM2-ATP1A2 associated with migraine and potassium channel
1) Confidence 0.74 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1236929 Disease Relevance 1.28 Pain Relevance 1.23
1A subunit of the neuronal voltage-gated calcium channel Cav2.1 (neuronal P/Q-type calcium channel) [12]; ATP1A2 gene localised to chromosome 1q21–23, implicated in FHM type 2 (FHM2) encoding for the ?
Localization (localised) of ATP1A2 in neuronal associated with migraine and calcium channel
2) Confidence 0.72 Published 2007 Journal J Headache Pain Section Body Doc Link PMC2779399 Disease Relevance 2.07 Pain Relevance 1.81

General Comments

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