INT186510

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.60
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (KCNN3)
Anatomy Link Frequency
SK-BR-3 1
MCF-7 1
KCNN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
potassium channel 14 100.00 Very High Very High Very High
Calcium channel 20 99.72 Very High Very High Very High
Migraine 152 97.56 Very High Very High Very High
Action potential 4 86.40 High High
Neuronal excitability 2 83.28 Quite High
Central nervous system 2 80.40 Quite High
Neurotransmitter 10 41.84 Quite Low
Serotonin 8 31.36 Quite Low
Dopamine 2 28.88 Quite Low
headache 12 21.04 Low Low
Disease Link Frequency Relevance Heat
Migraine With Aura 62 98.36 Very High Very High Very High
Headache 124 97.12 Very High Very High Very High
Migraine Without Aura 40 96.52 Very High Very High Very High
Spinocerebellar Ataxia Type 2 4 65.68 Quite High
Neurological Disease 12 57.68 Quite High
Channelopathies 4 54.72 Quite High
Breast Cancer 80 50.00 Quite Low
Disease 24 26.84 Quite Low
Hyperacusis 2 9.92 Low Low
Photophobia 2 9.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since FHM2-ATP1A2 is partly a potassium channel gene and is localised nearby to the potassium channel KCNN3, it may be interesting to investigate this gene in the common forms of migraine.
Localization (localised) of KCNN3 associated with migraine and potassium channel
1) Confidence 0.75 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1236929 Disease Relevance 1.25 Pain Relevance 1.21
KCNN3, localized at C1q21.3 [15], is positioned close to familial hemiplegic migraine (FHM) type 2, C1q23 [9,18], which is a severe autosomal dominant type of MA [1].
Localization (localized) of KCNN3 associated with migraine with aura and migraine
2) Confidence 0.71 Published 2005 Journal BMC Med Genet Section Body Doc Link PMC1236929 Disease Relevance 0.36 Pain Relevance 0.45
Our data indicated high-level gains at the c-MYC locus in SK-BR-3 and MCF-7 (+2.84 and +1.19 log2 ratios, respectively) corresponding to previously reported change in copy number [7,37,38].
Localization (locus) of SK-BR-3 in MCF-7
3) Confidence 0.15 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0 Pain Relevance 0
Our data indicated high-level gains at the c-MYC locus in SK-BR-3 and MCF-7 (+2.84 and +1.19 log2 ratios, respectively) corresponding to previously reported change in copy number [7,37,38].
Localization (locus) of SK-BR-3 in SK-BR-3
4) Confidence 0.05 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1413994 Disease Relevance 0 Pain Relevance 0

General Comments

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