INT186520

Context Info Confidence 0.56 First Reported 2005 Last Reported 2008 Negated 1 Speculated 0 Reported most in Body Documents 8 Total Number 10 Disease Relevance 8.22 Pain Relevance 1.00

signal transduction (CHKA) lipid metabolic process (CHKA) cytoplasm (CHKA) signal transducer activity (CHKA)

Anatomy Link Frequency thyroid 1 BxPC-3 1 DBTRG-05MG 1 RG2 1 CHKA (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 2 94.96 narcan 18 94.32 imagery 14 92.96 Angina 8 91.52 Enkephalin 4 77.48 Opioid 26 75.96 antagonist 23 72.16 agonist 36 60.80 fibrosis 22 34.84 opioid receptor 16 5.00

Disease Link Frequency Relevance Heat Thyroid Neoplasm 4 99.90 Heart Rate Under Development 16 99.84 Death 92 98.60 Myocardial Infarction 22 97.48 Carcinoma 7 97.24 Brain Tumor 22 97.08 Malignant Neoplastic Disease 18 96.60 Apoptosis 220 95.28 Thyroid Nodule 1 94.48 Hepatocellular Cancer 104 93.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

More recently, analysis from the Thrombolysis and Angioplasty in Myocardial Infarction (TAMI-7) trial of accelerated alteplase in patients presenting with ST-segment elevations showed a clear correlation between CK-MB peak and AUC values and development of CHF and a composite of CHF and death [17].

Gene_expression (development) of CK associated with heart rate under development, death and myocardial infarction

1) Confidence 0.56 Published 2005 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC1236947 Disease Relevance 0.85 Pain Relevance 0.09

Analysis of the expression of the cell cycle inhibitor p27 revealed that OGF treatment had no significant effect on expression levels of this CKI (Fig. 4). p57 protein was not detected on Western blots (1:200 dilution) of BxPC-3 cells.

Gene_expression (expression) of CKI in BxPC-3

2) Confidence 0.34 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2253554 Disease Relevance 0.26 Pain Relevance 0.29

OGF treatment increased cyclin-dependent kinase inhibitor (CKI) p21 protein expression in comparison to controls, as well levels of p21 complexed with Cdk2.

Gene_expression (expression) of CKI

3) Confidence 0.26 Published 2008 Journal Mol Cancer Section Abstract Doc Link PMC2253554 Disease Relevance 0.71 Pain Relevance 0.20

Immunohistochemical staining showed that the thyroid carcinoma was negative for thyroid transcription factor-1 (TTF-1), CK 7, CK 20, and thyroglobulin.

Neg (negative) Gene_expression (negative) of CK in thyroid associated with thyroid neoplasm

4) Confidence 0.22 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.43 Pain Relevance 0

in the transformed foci, and an overexpression of the CKi p27kip1 in

Gene_expression (overexpression) of CKi

5) Confidence 0.14 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.50 Pain Relevance 0

in the transformed foci, and an overexpression of the CKi p27kip1 in

Gene_expression (overexpression) of CKi

6) Confidence 0.12 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.50 Pain Relevance 0

increase in the mRNA and protein expression of the Cyclin-dependent kinase inhibitor (Cki) p21waf1/cip1 and also an increase in protein expression only of p27kip1, another CKi.

Gene_expression (expression) of CKi

7) Confidence 0.09 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.17 Pain Relevance 0.09

BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.

Gene_expression (expression) of CKI in DBTRG-05MG

8) Confidence 0.06 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.73 Pain Relevance 0.17

The brake: the IAP/Survivin/Cki submodule

Gene_expression (submodule) of Cki

9) Confidence 0.05 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.33 Pain Relevance 0

BP up-regulated the expression of Cyclin Kinase Inhibitor (CKI), including p21 and p27, to decrease phosphorylation of Rb proteins, and down-regulated the cell-cycle regulators, resulting in cell arrest at the G0/G1 phase for DBTRG-05MG and RG2 cells, respectively.

Gene_expression (expression) of CKI in RG2

10) Confidence 0.02 Published 2006 Journal Journal of Neurochemistry Section Abstract Doc Link PMC1804119 Disease Relevance 1.73 Pain Relevance 0.17

General Comments

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