INT186541

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.29
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ADRA1A) aging (ADRA1A) plasma membrane (ADRA1A)
cell-cell signaling (ADRA1A) response to stress (ADRA1A) signal transducer activity (ADRA1A)
Anatomy Link Frequency
adrenal medulla 1
PVN 1
ADRA1A (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 18 100.00 Very High Very High Very High
medulla 24 94.96 High High
Locus ceruleus 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Nerve growth factor 2 5.00 Very Low Very Low Very Low
Catecholamine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metabolic Syndrome 28 95.40 Very High Very High Very High
Stress 36 93.88 High High
Rickets 4 85.36 High High
Polycystic Ovary Syndrome 66 75.00 Quite High
Pressure And Volume Under Development 54 75.00 Quite High
Insulin Resistance 26 71.88 Quite High
Hyperandrogenism 12 70.36 Quite High
Metabolic Disorder 4 67.36 Quite High
Disease 8 11.52 Low Low
Cardiovascular Disease 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PCO rats had significantly higher MSAP than controls, higher levels of alpha1a adrenoceptor mRNA in the hypothalamic paraventricular nucleus (PVN), and lower levels of alpha2a adrenoceptor mRNA in the PVN and adrenal medulla.
Positive_regulation (levels) of alpha1a adrenoceptor in PVN associated with medulla
1) Confidence 0.45 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1236959 Disease Relevance 0.97 Pain Relevance 0.09
-MSH to the G-protein-coupled receptor melanocortin 1 receptor (MC1R), activating adenylate cyclase and increasing cAMP formation.
Positive_regulation (increasing) of G-protein-coupled receptor melanocortin 1 receptor associated with melanocortin 1 receptor
2) Confidence 0.30 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684124 Disease Relevance 0.17 Pain Relevance 0.34
-MSH to the G-protein-coupled receptor melanocortin 1 receptor (MC1R), activating adenylate cyclase and increasing cAMP formation.
Positive_regulation (activating) of G-protein-coupled receptor melanocortin 1 receptor associated with melanocortin 1 receptor
3) Confidence 0.30 Published 2007 Journal Evolutionary Bioinformatics Online Section Body Doc Link PMC2684124 Disease Relevance 0.17 Pain Relevance 0.34
The PCO rats had significantly higher MSAP than controls, higher levels of alpha1a adrenoceptor mRNA in the hypothalamic paraventricular nucleus (PVN), and lower levels of alpha2a adrenoceptor mRNA in the PVN and adrenal medulla.
Positive_regulation (levels) of alpha1a adrenoceptor in adrenal medulla associated with medulla
4) Confidence 0.15 Published 2005 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC1236959 Disease Relevance 0.97 Pain Relevance 0.09

General Comments

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