INT186566

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.17
First Reported 2005
Last Reported 2005
Negated 3
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 0.38
Pain Relevance 4.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Fos) nucleolus (Fos) nucleus (Fos)
DNA binding (Fos) transcription factor binding (Fos) response to stress (Fos)
Anatomy Link Frequency
spinal cord 4
posterior 1
stomach 1
Hpcl1 (Rattus norvegicus)
Fos (Rattus norvegicus)
Pain Link Frequency Relevance Heat
qutenza 474 100.00 Very High Very High Very High
Spinal cord 282 99.68 Very High Very High Very High
Dorsal horn 12 98.96 Very High Very High Very High
Root ganglion neuron 18 98.78 Very High Very High Very High
ASIC 12 92.72 High High
medulla 102 89.24 High High
superficial lamina 6 72.40 Quite High
abdominal pain 6 42.04 Quite Low
Pain 12 5.00 Very Low Very Low Very Low
Angina 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 24 98.62 Very High Very High Very High
Pressure And Volume Under Development 24 96.48 Very High Very High Very High
Injury 24 56.00 Quite High
Nociception 24 55.56 Quite High
Abdominal Pain 6 42.04 Quite Low
Pain 12 5.00 Very Low Very Low Very Low
Disease 12 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 12 5.00 Very Low Very Low Very Low
Ulcers 6 5.00 Very Low Very Low Very Low
Overdose 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study confirms that excess gastric HCl fails to induce c-fos mRNA and c-Fos protein in the dorsal horn of the posterior thoracic spinal cord [5,7] which receives the densest input from afferent neurons innervating the rat stomach [17,18].
HCl Neg (fails) Positive_regulation (induce) of c-fos mRNA in posterior associated with dorsal horn and spinal cord
1) Confidence 0.17 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.06 Pain Relevance 0.35
Since both TRPV1 and ASIC3 are expressed by a majority of dorsal root ganglion neurons supplying the rat stomach [16], it appears unlikely that IG HCl fails to induce c-fos mRNA in the spinal cord because the respective afferents do not bear the appropriate acid sensors.
HCl Neg (fails) Positive_regulation (induce) of c-fos mRNA in stomach associated with ganglion cysts, root ganglion neuron and spinal cord
2) Confidence 0.17 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.10 Pain Relevance 0.67
There are other ways to explain the differential ability of IG HCl and capsaicin to induce c-fos mRNA in the NTS and spinal cord, but the analysis of these factors was beyond the scope of this study.
HCl Positive_regulation (induce) of c-fos mRNA in spinal cord associated with qutenza and spinal cord
3) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0 Pain Relevance 0.97
In contrast, intragastric HCl failed to induce c-fos mRNA in the spinal cord.
HCl Neg (failed) Positive_regulation (induce) of c-fos mRNA in spinal cord associated with spinal cord
4) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1239919 Disease Relevance 0.15 Pain Relevance 1.03
Effects of HCl and capsaicin to induce c-fos mRNA in the NTS and spinal cord (study 1)
HCl Positive_regulation (induce) of c-fos mRNA in spinal cord associated with qutenza and spinal cord
5) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0 Pain Relevance 0.65
In view of this finding it can be ruled out that c-fos expression is an inadequate method to visualize chemoreceptor signalling from the gastric lumen to the spinal cord and that the failure of gastric HCl challenge to induce c-fos mRNA in the spinal cord represents a false negative result.
HCl Positive_regulation (induce) of c-fos mRNA in spinal cord associated with spinal cord
6) Confidence 0.12 Published 2005 Journal BMC Neurosci Section Body Doc Link PMC1239919 Disease Relevance 0.07 Pain Relevance 0.82

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox