INT18658

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Context Info
Confidence 0.62
First Reported 1980
Last Reported 2007
Negated 9
Speculated 4
Reported most in Abstract
Documents 34
Total Number 38
Disease Relevance 5.69
Pain Relevance 13.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Adra1a) plasma membrane (Adra1a) cellular_component (Adra1a)
response to stress (Adra1a) signal transducer activity (Adra1a)
Anatomy Link Frequency
brain 2
vas deferens 2
blood 2
nerves 2
aorta 1
Adra1a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 62 100.00 Very High Very High Very High
antagonist 40 100.00 Very High Very High Very High
anesthesia 5 100.00 Very High Very High Very High
dopamine receptor 2 100.00 Very High Very High Very High
narcan 7 99.84 Very High Very High Very High
Clonidine 72 99.82 Very High Very High Very High
Kinase C 7 99.36 Very High Very High Very High
cerebral cortex 13 99.10 Very High Very High Very High
cocaine 18 98.92 Very High Very High Very High
tolerance 1 98.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 6 100.00 Very High Very High Very High
Vibrio Infection 2 100.00 Very High Very High Very High
Lordosis 7 99.84 Very High Very High Very High
Anxiety Disorder 6 99.80 Very High Very High Very High
Hypertension 17 98.96 Very High Very High Very High
Aging 2 98.68 Very High Very High Very High
Cv Unclassified Under Development 5 98.36 Very High Very High Very High
Injury 1 98.10 Very High Very High Very High
Benign Prostatic Hypertrophy 7 97.68 Very High Very High Very High
Pain 1 97.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neonatal 6-hydroxydopamine treatment was used to destroy the noradrenergic nerve terminals in rat cerebral cortex and thus give some insight into the in vivo regulation of alpha-adrenoceptor subtypes, which in turn provides information concerning the anatomical localization of alpha 1- and alpha 2-adrenoceptors.
Regulation (regulation) of alpha-adrenoceptor in nerve associated with cerebral cortex
1) Confidence 0.62 Published 1982 Journal Eur. J. Pharmacol. Section Abstract Doc Link 6281028 Disease Relevance 0 Pain Relevance 0.28
Effects of cooling on alpha-1-adrenoceptor mechanisms in rat aorta.
Regulation (Effects) of alpha-1-adrenoceptor in aorta
2) Confidence 0.45 Published 1988 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Title Doc Link 2904878 Disease Relevance 0 Pain Relevance 0.25
The effects of cooling from 37 degrees C to 25 degrees C on alpha-1-adrenoceptor mechanisms in isolated rat aortic strips were studied. 2.
Regulation (effects) of alpha-1-adrenoceptor
3) Confidence 0.45 Published 1988 Journal Comp. Biochem. Physiol. C, Comp. Pharmacol. Toxicol. Section Abstract Doc Link 2904878 Disease Relevance 0 Pain Relevance 0.22
Microdialysis technique was used to study the effects of the locally applied alpha adrenoceptor agonist phenylephrine and antagonist phentolamine on the basal noradrenaline efflux as well as on the noradrenaline uptake inhibitor desipramine-elicited noradrenaline efflux in the nucleus accumbens (NAc) of freely moving rats.
Regulation (effects) of alpha adrenoceptor in nucleus accumbens associated with nucleus accumbens, desipramine, antagonist, noradrenaline and agonist
4) Confidence 0.45 Published 2007 Journal J Neural Transm Section Abstract Doc Link 17533511 Disease Relevance 0 Pain Relevance 0.74
The effects of alpha-adrenoceptor and dopaminoceptor agonists and antagonists were investigated on presynaptic receptors in the prostatic portion of rat vas deferens.
Regulation (effects) of alpha-adrenoceptor in vas deferens associated with antagonist and agonist
5) Confidence 0.45 Published 1986 Journal Acta Physiol Pharmacol Latinoam Section Abstract Doc Link 3033993 Disease Relevance 0 Pain Relevance 0.41
The vasodilator nitroprusside or the alpha 1-adrenoreceptor antagonist prazosin did not affect baroreceptor responses to cocaine.
Neg (not) Regulation (affect) of alpha 1-adrenoreceptor associated with antagonist and cocaine
6) Confidence 0.45 Published 1990 Journal Am. J. Physiol. Section Abstract Doc Link 2331013 Disease Relevance 0.14 Pain Relevance 0.76
Effects of alpha1-adrenoceptor antagonists on agonist and tilt-induced changes in blood pressure: relationships to uroselectivity.
Regulation (Effects) of alpha1-adrenoceptor in blood associated with anesthesia, antagonist, cv unclassified under development and agonist
7) Confidence 0.44 Published 1999 Journal Eur. J. Pharmacol. Section Title Doc Link 10408251 Disease Relevance 0.10 Pain Relevance 0.29
We studied the effects of alpha 1-adrenoceptor blockade with indoramin on exercise tolerance in 15 patients with chronic stable angina using a double-blind crossover protocol.
Regulation (effects) of alpha 1-adrenoceptor associated with angina and tolerance
8) Confidence 0.44 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2423788 Disease Relevance 0.15 Pain Relevance 0.17
The present study investigated the effects of WB4101, a selective alpha 1-adrenoceptor blocking agent, and idazoxan, a selective alpha 2-adrenoceptor blocking agent, on antinociception and sedation in the rat mediated by adrenoceptors.
Spec (investigated) Regulation (effects) of alpha 1-adrenoceptor associated with antinociception and sleep disorders
9) Confidence 0.43 Published 1986 Journal Neuropharmacology Section Abstract Doc Link 2872610 Disease Relevance 0.17 Pain Relevance 0.52
The object of the study was to investigate the effects of dopamine receptor and alpha-adrenoreceptor agonists and antagonists on the gastric emptying of a liquid test meal in conscious rats and the possible involvement of these receptors in the mechanism of action of metoclopramide.
Spec (investigate) Regulation (effects) of alpha-adrenoreceptor associated with antagonist, dopamine receptor and agonist
10) Confidence 0.41 Published 1985 Journal J Auton Pharmacol Section Abstract Doc Link 2869043 Disease Relevance 0.08 Pain Relevance 0.29
The effects of various alpha adrenoceptor agonists and antagonists injected into the spinal subarachnoid space on blood pressure and heart rate were investigated in pentobarbital-anesthetized male rats.
Spec (investigated) Regulation (effects) of alpha adrenoceptor in spinal associated with antagonist and agonist
11) Confidence 0.41 Published 1987 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2879903 Disease Relevance 0.21 Pain Relevance 0.28
In conclusion, it is demonstrated that after chronic imipramine treatment the peripheral alpha 2-adrenoceptors (both presynaptic and postsynaptic sites) as well as central alpha 2-adrenoceptors respond with a decreased sensitivity to the alpha 2-adrenoceptor agonists, and moreover, this treatment produces an increased sensitivity of the central and peripheral alpha 1-adrenoceptors to the alpha 1-adrenoceptor full agonists.
Regulation (sensitivity) of 1-adrenoceptor associated with agonist
12) Confidence 0.39 Published 1987 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2895612 Disease Relevance 0 Pain Relevance 0.29
We have looked at the role played by alpha 1 and alpha 2 adrenoceptors in the control of blood pressure in the anaesthetised spontaneously hypertensive rat (SHR) by examining the blood-pressure-lowering effects of the alpha 1-adrenoceptor antagonist prazosin and the alpha 2-adrenoceptor antagonist rauwolscine in 5 groups of animals: unoperated, adrenal demedullated, shamoperated, sympathectomised with 6-hydroxydopamine, and vehicle treated.
Regulation (effects) of alpha 1-adrenoceptor in blood associated with antagonist and hypertension
13) Confidence 0.39 Published 1986 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2419696 Disease Relevance 0.17 Pain Relevance 0.10
The pressor responses to intravenously administered noradrenaline (0.01-10 micrograms/kg) and electrical stimulation of the spinal sympathetic nerves (SNS, 0.25-2 Hz) were similar in the two groups, suggesting that salt did not influence vascular alpha-adrenoceptor responsiveness or transmitter release.
Neg (not) Regulation (influence) of alpha-adrenoceptor in nerves associated with noradrenaline
14) Confidence 0.39 Published 1987 Journal Pharmacol. Toxicol. Section Abstract Doc Link 3035531 Disease Relevance 0 Pain Relevance 0.52
In pentobarbital-anesthetized rats, pressor responses to i.c.v. injection of alpha 1- and alpha 2-adrenoceptor agonists were significantly inhibited and a long-lasting depressor response was induced by alpha 2-adrenoceptor agonists, whereas depressor responses to alpha 1-adrenoceptor agonists were not affected.
Regulation (responses) of 1-adrenoceptor associated with agonist
15) Confidence 0.39 Published 1987 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 2892472 Disease Relevance 0.25 Pain Relevance 0.39
Modulation of rat brain alpha-adrenoreceptor populations four weeks after stimulation of the nucleus locus coeruleus.
Regulation (Modulation) of brain alpha-adrenoreceptor in brain associated with locus ceruleus
16) Confidence 0.37 Published 1981 Journal Psychopharmacology (Berl.) Section Title Doc Link 6267649 Disease Relevance 0.05 Pain Relevance 0.43
Conversely, the specific alpha-1-adrenoceptor antagonist prazosin blocked the anxiogenic-like effect but did not alter the anxiolytic-like activity.
Neg (not) Regulation (alter) of alpha-1-adrenoceptor associated with antagonist and anxiety disorder
17) Confidence 0.35 Published 1988 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2845446 Disease Relevance 0.43 Pain Relevance 0.28
The effect of the alpha adrenoceptor blocking agent yohimbine on cerebral dopamine metabolism has been investigated in the rat.
Regulation (effect) of alpha adrenoceptor associated with dopamine
18) Confidence 0.34 Published 1980 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7192314 Disease Relevance 0 Pain Relevance 0.18
Selectivity of benzodioxane alpha-adrenoceptor antagonists for alpha 1- and alpha 2-adrenoceptors determined by binding affinity.
Regulation (Selectivity) of benzodioxane alpha-adrenoceptor associated with antagonist
19) Confidence 0.32 Published 1983 Journal Pharmacology Section Title Doc Link 6134295 Disease Relevance 0 Pain Relevance 0.20
Effects of pertussis and cholera toxins on alpha-adrenoceptor function in rat tail artery: differences in hypertension.
Regulation (Effects) of alpha-adrenoceptor in tail associated with bordatella infection, hypertension and vibrio infection
20) Confidence 0.28 Published 1993 Journal Can. J. Physiol. Pharmacol. Section Title Doc Link 7908252 Disease Relevance 1.05 Pain Relevance 0.45

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