INT186593

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2005
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 6
Disease Relevance 3.94
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (SFRP5) signal transduction (SFRP5) extracellular space (SFRP5)
extracellular region (SFRP5) plasma membrane (SFRP5) embryo development (SFRP5)
Anatomy Link Frequency
plasma 2
SFRP5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 6 88.96 High High
cINOD 6 87.12 High High
Crohn's disease 6 84.28 Quite High
rheumatoid arthritis 6 83.48 Quite High
Morphine 6 80.28 Quite High
Infliximab 6 79.00 Quite High
palliative 6 74.72 Quite High
dexamethasone 6 44.68 Quite Low
Disease Link Frequency Relevance Heat
Cardiovascular Disorder Under Development 12 99.88 Very High Very High Very High
Disease 54 98.52 Very High Very High Very High
Cancer 306 97.80 Very High Very High Very High
Disease Progression 18 96.60 Very High Very High Very High
Adverse Drug Reaction 6 94.80 High High
Breast Cancer 24 92.56 High High
Prostate Cancer 24 90.32 High High
Fever 6 88.96 High High
INFLAMMATION 12 88.60 High High
Toxicity 102 85.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recombinant scFv(FRP5)-ETA was produced as an experimental drug under Good Manufacturing Practice conditions and was kindly provided by Ciba Geigy AG (Basel, Switzerland).
Gene_expression (produced) of FRP5
1) Confidence 0.16 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.20 Pain Relevance 0.07
No scFv(FRP5)-ETA could be detected in patient plasma at the 2 ?
Gene_expression (detected) of FRP5 in plasma
2) Confidence 0.16 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.81 Pain Relevance 0.12
Complete or partial remissions were not observed after scFv(FRP5)-ETA treatment, which was not unexpected given the severity of the patients' disease and their tumor load.
Neg (not) Gene_expression (unexpected) of FRP5 associated with cancer and disease
3) Confidence 0.14 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 1.19 Pain Relevance 0.05
Detection of scFv(FRP5)-ETA plasma levels by sandwich ELISA
Gene_expression (Detection) of FRP5 in plasma
4) Confidence 0.14 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.71 Pain Relevance 0
Only in five patients, however, could antibodies with neutralizing capacity against scFv(FRP5)-ETA be detected in cell viability assays.
Gene_expression (detected) of FRP5
5) Confidence 0.13 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.11 Pain Relevance 0
The mAb FRP5 and its scFv derivatives recognize a peptide epitope located in the N-terminal region of the receptor [14,31].
Gene_expression (derivatives) of FRP5
6) Confidence 0.12 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.92 Pain Relevance 0.21

General Comments

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