INT186597

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.36
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EEF2) translation (EEF2) GTPase activity (EEF2)
cytoplasm (EEF2)
EEF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
dexamethasone 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
rheumatoid arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 7 97.96 Very High Very High Very High
Cancer 51 97.20 Very High Very High Very High
Diphtheria 1 96.88 Very High Very High Very High
Vibrio Infection 1 96.58 Very High Very High Very High
Apoptosis 2 96.40 Very High Very High Very High
Poisoning 7 85.44 High High
Pseudomonas Infection 1 79.96 Quite High
Ovarian Cancer 1 67.28 Quite High
Skin Cancer 1 64.88 Quite High
Prostate Cancer 4 61.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increasing serum insulin concentration during the mixed amino acid infusion produced insulin dose-related increases in the phosphorylation status of PKB Ser473 and p70S6k Thr389 and dose-related decreases in eEF2 Thr56 phosphorylation status relative to the values at 5 mU/l (Fig. 5A).
Negative_regulation (decreases) of eEF2
1) Confidence 0.25 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
The toxin’s structure is similar to insulin, ricin, botulinum, cholera and diphtheria toxins.1 The B chain facilitates binding to cell surface receptors, allowing the entry of the A chain into cells.4 The A chain acts on the 60s ribosome to inhibit EF-1 and EF-2, preventing protein synthesis and leading to cell death.1,5
Negative_regulation (inhibit) of EF-2 associated with vibrio infection, diphtheria and death
2) Confidence 0.09 Published 2008 Journal Western Journal of Emergency Medicine Section Body Doc Link PMC2672262 Disease Relevance 0.38 Pain Relevance 0
Toxin-mediated inactivation of elongation factor 2 causes the inhibition of protein synthesis and results in subsequent tumor cell death by apoptosis [13,14].
Negative_regulation (inactivation) of elongation factor 2 associated with cancer, apoptosis and death
3) Confidence 0.02 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1242130 Disease Relevance 0.98 Pain Relevance 0

General Comments

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