INT18660

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Context Info
Confidence 0.41
First Reported 1982
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 45
Total Number 46
Disease Relevance 10.60
Pain Relevance 16.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gnrhr) signal transducer activity (Gnrhr)
Anatomy Link Frequency
pituitary 5
hypothalamus 3
choroid plexus 2
forebrain 2
sella 1
Gnrhr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 31 100.00 Very High Very High Very High
Enkephalin 23 100.00 Very High Very High Very High
antagonist 18 100.00 Very High Very High Very High
agonist 18 100.00 Very High Very High Very High
opiate 10 100.00 Very High Very High Very High
Serotonin 6 100.00 Very High Very High Very High
excitatory amino acid 1 100.00 Very High Very High Very High
headache 5 99.98 Very High Very High Very High
rheumatoid arthritis 11 99.92 Very High Very High Very High
Dynorphin 11 99.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Growth Hormone Deficiency 16 100.00 Very High Very High Very High
Craniopharyngioma 6 100.00 Very High Very High Very High
Thyroid Disease 2 100.00 Very High Very High Very High
Precocious Puberty 10 99.98 Very High Very High Very High
Headache 2 99.98 Very High Very High Very High
Rheumatoid Arthritis 11 99.92 Very High Very High Very High
Burns 4 99.84 Very High Very High Very High
Empty Sella Syndrome 1 99.64 Very High Very High Very High
Cancer 10 99.56 Very High Very High Very High
Pituitary Cancer 5 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Under control incubation conditions, gonadotropin-releasing hormone (GnRH) binds only a fraction of its receptors in rat-cultivated pituitary cells.
gonadotropin-releasing hormone Binding (binds) of in pituitary
1) Confidence 0.41 Published 1998 Journal Neuroendocrinology Section Abstract Doc Link 9873202 Disease Relevance 0 Pain Relevance 0.07
When tolerance to morphine was developed, the level of growth hormone-binding was restored to control level.
growth hormone Binding (binding) of associated with tolerance and morphine
2) Confidence 0.38 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7724051 Disease Relevance 0 Pain Relevance 0.50
Decreased binding of growth hormone in the rat hypothalamus and choroid plexus following morphine treatment.
growth hormone Binding (binding) of in hypothalamus associated with morphine
3) Confidence 0.38 Published 1995 Journal Neurosci. Lett. Section Title Doc Link 7724051 Disease Relevance 0 Pain Relevance 0.49
The binding of rat growth hormone (rGH) to specific sites in choroid plexus, cortex, hypothalamus, hippocampus and striatum was determined.
growth hormone Binding (binding) of in cortex associated with hippocampus
4) Confidence 0.38 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7724051 Disease Relevance 0 Pain Relevance 0.42
Isosexual precocious puberty in girls is not uncommon, but its association with craniopharyngioma and growth hormone deficiency is rarely reported.
growth hormone Binding (association) of associated with craniopharyngioma, precocious puberty and growth hormone deficiency
5) Confidence 0.35 Published 2001 Journal Acta Paediatr Taiwan Section Abstract Doc Link 11550415 Disease Relevance 0.74 Pain Relevance 0.07
We report here the case of a 21-year-old woman with a large sellar tumor, extending to the suprasellar area associated with growth hormone deficiency, hypogonadism, hypocorticism, and hyperprolactinemia.
growth hormone Binding (associated) of associated with galactorrhea, reprotox - general 2, cancer and growth hormone deficiency
6) Confidence 0.35 Published 2007 Journal Endocr. Pathol. Section Abstract Doc Link 17916999 Disease Relevance 0.71 Pain Relevance 0
In addition to lowering circulating growth hormone levels and shrinking tumor size, octreotide may provide symptomatic relief of headaches associated with growth hormone secreting tumors.
growth hormone Binding (associated) of associated with cancer and headache
7) Confidence 0.35 Published 2000 Journal Pituitary Section Abstract Doc Link 11383484 Disease Relevance 0.78 Pain Relevance 0.15
In agreement with this model, a recent study (Wiesbeck et al., 1995) showed an association between growth hormone response to apomorphine, an indirect assessment of the dopaminergic system, and novelty seeking score in alcohol-dependent men.
growth hormone Binding (association) of associated with alcohol
8) Confidence 0.35 Published 1998 Journal Psychoneuroendocrinology Section Abstract Doc Link 9802122 Disease Relevance 0.16 Pain Relevance 0.21
Physiological and pharmacological evidence has suggested that both endogenous opiates and gonadotropin-releasing hormone (GnRH) itself can act centrally to exert a tonic inhibition on gonadotropin secretion via an inhibition of the neurosecretion of GnRH.
gonadotropin-releasing hormone Binding (opiates) of associated with opiate
9) Confidence 0.33 Published 1989 Journal J. Comp. Neurol. Section Abstract Doc Link 2671062 Disease Relevance 0 Pain Relevance 0.10
We have examined the pharmacology of the voltage-sensitive Ca2+ channels (VSCCs) that mediate gonadotropin secretion from primary cultures of rat pituitary cells, stimulated by either cell depolarization or by binding of gonadotropin-releasing hormone (GnRH).
gonadotropin-releasing hormone Binding (binding) of in pituitary
10) Confidence 0.32 Published 1990 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 2170211 Disease Relevance 0 Pain Relevance 0.09
These falls occurred earlier than the rise in growth hormone, which rose to a maximum of 23 and 20 IU/ml respectively at 45 minutes after dosing.
growth hormone Binding (rose) of
11) Confidence 0.32 Published 1984 Journal Hypertension Section Abstract Doc Link 6150000 Disease Relevance 0.09 Pain Relevance 0.43
Severe burns induce a hypermetabolic response that may result in peripheral wasting, that depletes substrates necessary for tissue repair, and is associated with reduced growth hormone.
growth hormone Binding (associated) of associated with burns
12) Confidence 0.31 Published 2001 Journal Sleep Section Abstract Doc Link 11204053 Disease Relevance 1.04 Pain Relevance 0.19
The condition is associated with obesity and growth surges, and it is occasionally associated with endocrine disorders such as hypothyroidism, growth hormone supplementation, hypogonadism, and panhypopituitarism.
growth hormone Binding (associated) of associated with reprotox - general 2, thyroid disease, obesity and hypopituitarism
13) Confidence 0.30 Published 2010 Journal Am Fam Physician Section Abstract Doc Link 20672790 Disease Relevance 0.55 Pain Relevance 0.09
We studied whether Na+ and Ca2+ channels are involved in the neural mechanism responsible for the surge of gonadotropin-releasing hormone (GnRH) in proestrous rats.
gonadotropin-releasing hormone Binding (surge) of in neural
14) Confidence 0.29 Published 2003 Journal Endocr. J. Section Abstract Doc Link 12803234 Disease Relevance 0 Pain Relevance 0.26
Precocious puberty associated with growth hormone deficiency in a patient with craniopharyngioma: report of one case.
growth hormone Binding (associated) of associated with craniopharyngioma, precocious puberty and growth hormone deficiency
15) Confidence 0.27 Published 2001 Journal Acta Paediatr Taiwan Section Title Doc Link 11550415 Disease Relevance 1.19 Pain Relevance 0.08
Interactions between the effects of opioid, serotonin and alpha-2-adrenergic receptor agonists on growth hormone release in the male rat.
growth hormone Binding (Interactions) of associated with agonist, serotonin and opioid
16) Confidence 0.26 Published 1993 Journal Neuroendocrinology Section Title Doc Link 8105397 Disease Relevance 0 Pain Relevance 1.09
The role of endogenous opiate peptides in the mesencephalic central gray (MCG) and their possible interactions with gonadotropin-releasing hormone (GnRH) in the regulation of lordosis behavior was assessed in ovariectomized, estrogen-treated and estrogen-progesterone-treated female rats.
gonadotropin-releasing hormone Binding (interactions) of in central gray associated with opiate and lordosis
17) Confidence 0.26 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6209590 Disease Relevance 0.26 Pain Relevance 0.35
The decrease in growth hormone-binding in these regions of the rat brain was also confirmed by SDS-polyacrylamide gel electrophoresis of cross-linked complexes of the binding entities to 125I-labelled rGH as visualized by autoradiography.
growth hormone Binding (binding) of in brain
18) Confidence 0.24 Published 1995 Journal Neurosci. Lett. Section Abstract Doc Link 7724051 Disease Relevance 0 Pain Relevance 0.51
Lipopolysaccharide inhibits luteinizing hormone release through interaction with opioid and excitatory amino acid inputs to gonadotropin-releasing hormone neurones in female rats: possible evidence for a common mechanism involved in infection and immobilization stress.
gonadotropin-releasing hormone Spec (possible) Binding (interaction) of associated with stress, narcan, opioid, infection and excitatory amino acid
19) Confidence 0.24 Published 2003 Journal J. Neuroendocrinol. Section Title Doc Link 12716406 Disease Relevance 0.29 Pain Relevance 0.31
A non-opioid pattern characterizes inhibition of growth hormone releasing peptide binding by dynorphin-related peptides.
growth hormone Binding (binding) of associated with dynorphin and opioid
20) Confidence 0.24 Published 1990 Journal Neuropeptides Section Title Doc Link 1979153 Disease Relevance 0 Pain Relevance 0.82

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