INT18661

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 32
Total Number 32
Disease Relevance 3.19
Pain Relevance 5.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ghsr) signal transducer activity (Ghsr)
Anatomy Link Frequency
pituitary 2
hypothalamus 1
testis 1
thyrotrope 1
somatotropes 1
Ghsr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 34 100.00 Very High Very High Very High
Somatostatin 27 100.00 Very High Very High Very High
opiate 38 99.90 Very High Very High Very High
Enkephalin 6 96.08 Very High Very High Very High
Clonidine 7 95.20 Very High Very High Very High
tolerance 3 94.44 High High
Opioid 5 89.04 High High
antagonist 7 86.72 High High
Dynorphin 8 85.92 High High
Central nervous system 2 84.48 Quite High
Disease Link Frequency Relevance Heat
Aging 33 96.16 Very High Very High Very High
Hyperplasia 7 95.64 Very High Very High Very High
Hypothyroidism 6 94.88 High High
Hypoglycemia 1 90.12 High High
Growth Hormone Deficiency 23 89.00 High High
Insulin Resistance 2 83.04 Quite High
Hypopituitarism 5 78.00 Quite High
Gastric Motility Disorder 8 73.40 Quite High
Diabetes Mellitus 13 64.72 Quite High
Weight Gain 2 61.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
GH-releasing peptide (His-DTrp-Ala-Trp-DPhe-Lys-NH2 or GHRP) releases GH by a unique and complementary dual site of action on the hypothalamus and pituitary.
Localization (releases) of GHRP in pituitary
1) Confidence 0.78 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.19
Since the GHRP plus GHRH synergistic GH release was not explained by inhibition of SRIF or stimulation of GHRH, an alternative mechanism is proposed to explain how GHRP synergistically release GH in combination with GHRH.
Localization (release) of GHRP associated with somatostatin
2) Confidence 0.78 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.67
Present data indicate that one of the major differences in the actions of dermorphin, 2549, and GHRP is the inhibition of somatostatin (SRIF) release by the opiates but not by GHRP.
Localization (release) of GHRP associated with somatostatin and opiate
3) Confidence 0.73 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.72
Moreover, GRF appears to access a more substantial pool of hormone which is not released by GHRP-6.
Neg (not) Localization (released) of GHRP-6
4) Confidence 0.73 Published 1988 Journal Life Sci. Section Abstract Doc Link 3123835 Disease Relevance 0 Pain Relevance 0
There appears, therefore, to be some species differences in the localisation of ghrelin protein in the testis.
Localization (localisation) of ghrelin protein in testis
5) Confidence 0.72 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1291400 Disease Relevance 0.06 Pain Relevance 0.03
Taken together, these results suggest that GHRP-6 causes the immediate release of a limited pool of GH which is present only in a discrete subpopulation of somatotropes that respond to GRF.
Localization (release) of GHRP-6 in somatotropes
6) Confidence 0.68 Published 1988 Journal Life Sci. Section Abstract Doc Link 3123835 Disease Relevance 0 Pain Relevance 0.06
In addition to stimulating GH release, GH secretagogues such as GH-releasing peptide-6 (GHRP-6) stimulate small amounts of ACTH and PRL release.
Localization (secretagogues) of GH-releasing peptide-6
7) Confidence 0.68 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
In addition to stimulating GH release, GH secretagogues such as GH-releasing peptide-6 (GHRP-6) stimulate small amounts of ACTH and PRL release.
Localization (secretagogues) of GHRP-6
8) Confidence 0.68 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
In addition to stimulating GH release, GH secretagogues such as GH-releasing peptide-6 (GHRP-6) stimulate small amounts of ACTH and PRL release.
Localization (releasing) of GH-releasing peptide-6
9) Confidence 0.68 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
In addition to stimulating GH release, GH secretagogues such as GH-releasing peptide-6 (GHRP-6) stimulate small amounts of ACTH and PRL release.
Localization (releasing) of GHRP-6
10) Confidence 0.68 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
In addition to stimulating GH release, GH secretagogues such as GH-releasing peptide-6 (GHRP-6) stimulate small amounts of ACTH and PRL release.
Localization (releasing) of GH-releasing peptide-6
11) Confidence 0.68 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
The new ghrelin receptor agonist, TZP-101, is promising as it did not induce growth hormone secretion following either peripheral or central administration [53].
Localization (secretion) of ghrelin receptor associated with agonist
12) Confidence 0.65 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2915793 Disease Relevance 0.45 Pain Relevance 0.17
These effects could be dissociated from GHRP-6-induced GH release in the same animals, but not from PRL release induced by TRH, which was also abolished by ovariectomy and induced in males by E2 treatment.
Localization (release) of GHRP-6-induced
13) Confidence 0.64 Published 1998 Journal Endocrinology Section Abstract Doc Link 9681512 Disease Relevance 0 Pain Relevance 0
Interestingly, when presented together in maximal concentrations, L-692,429 and GHRP-6 did not cause an additional GH release when compared with either secretagogue alone.
Localization (release) of GHRP-6
14) Confidence 0.63 Published 1993 Journal Horm. Res. Section Abstract Doc Link 7905455 Disease Relevance 0 Pain Relevance 0.24
Evidence indicates that these opiates and GHRP administered together synergistically release GH, demonstrating the independent action(s) of GHRP and the opiates.
Localization (release) of GHRP associated with opiate
15) Confidence 0.60 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.66
Under the same conditions, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2 (GH-releasing peptide, GHRP-6) and GH-releasing factor (GRF) had EC50 values of 10(-8) and 5 x 10(-10) M, respectively.
Localization (releasing) of GHRP-6
16) Confidence 0.60 Published 1993 Journal Horm. Res. Section Abstract Doc Link 7905455 Disease Relevance 0 Pain Relevance 0.23
Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency.
Localization (releasing) of GHRP-6
17) Confidence 0.50 Published 1996 Journal J. Pediatr. Endocrinol. Metab. Section Title Doc Link 8887178 Disease Relevance 0.38 Pain Relevance 0.09
GH-releasing peptide (His-DTrp-Ala-Trp-DPhe-Lys-NH2 or GHRP) releases GH by a unique and complementary dual site of action on the hypothalamus and pituitary.
Localization (releases) of GHRP in hypothalamus
18) Confidence 0.27 Published 1991 Journal Endocrinology Section Abstract Doc Link 2004615 Disease Relevance 0 Pain Relevance 0.19
Among ghrelin-related peptides examined (1 microM of rat ghrelin, human ghrelin, chicken ghrelin and growth hormone releasing peptide-6 (GHRP-6)), only chicken ghrelin was effective on contraction of the chicken gastrointestinal tract.
Localization (releasing) of GHRP-6
19) Confidence 0.26 Published 2007 Journal Peptides Section Abstract Doc Link 17145117 Disease Relevance 0 Pain Relevance 0.17
The GH releasing effects of either GHRH alone or GHRH+GHRP-6 were significantly more potent than that of GHRP-6 alone (p < 0.05).
Localization (releasing) of GHRP-6
20) Confidence 0.19 Published 1999 Journal J. Physiol. Biochem. Section Abstract Doc Link 10494658 Disease Relevance 0 Pain Relevance 0.08

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