INT186622

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.86
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
photoreceptors 1
HeLa 1
Brain 1
neural 1
Chol1 (Mus musculus)
Pain Link Frequency Relevance Heat
psoriasis 63 93.96 High High
chemokine 3 72.72 Quite High
Inflammation 44 67.64 Quite High
COX-2 inhibitor 13 62.80 Quite High
withdrawal 6 49.56 Quite Low
cOX1 1 18.36 Low Low
Kinase C 18 5.00 Very Low Very Low Very Low
cytokine 18 5.00 Very Low Very Low Very Low
Central nervous system 16 5.00 Very Low Very Low Very Low
cINOD 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 62 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 99.92 Very High Very High Very High
Psoriasis 106 99.84 Very High Very High Very High
Disease 167 99.04 Very High Very High Very High
Syndrome 9 98.82 Very High Very High Very High
Metabolic Syndrome 2 94.68 High High
Hypolipidemia 4 89.68 High High
Increased Venous Pressure Under Development 22 85.76 High High
Adverse Drug Reaction 3 84.96 Quite High
Coronary Artery Disease 15 84.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, patients with Smith-Lemli-Opitz Syndrome, a disease of abnormal cholesterol metabolism caused by a defect in 7-dehydrocholesterol reductase (DHCR7), another enzyme encoded by a gene selectively expressed in macula tissues, exhibited slower activation and recovery kinetics of their rod photoreceptors [61].
Negative_regulation (defect) of cholesterol in photoreceptors associated with syndrome and disease
1) Confidence 0.42 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.77 Pain Relevance 0
Atorvastatin had the most pronounced hypolipidemic effects with a 35% reduction in LDL cholesterol and 40% reduction in TG.
Negative_regulation (reduction) of cholesterol
2) Confidence 0.42 Published 2005 Journal BMC Cardiovasc Disord Section Abstract Doc Link PMC1262701 Disease Relevance 0.14 Pain Relevance 0
Among various drugs developed to reduce serum cholesterol levels and subsequent risk for coronary events, HMG-CoA reductase inhibitors (statins), have proven to be extremely useful drugs [2–5].
Negative_regulation (reduce) of cholesterol
3) Confidence 0.42 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2275764 Disease Relevance 0.80 Pain Relevance 0
However, it was shown that desmosterol in model membranes promotes the formation and stability of ordered domains somewhat less efficiently than cholesterol [53, 55], and recent data show that inhibition of 24-dehydrocholesterol reductase in HeLa cells increases the structural heterogeneity of caveolae due to a decreased affinity of caveolin-1 for sterol and a reduced stability of caveolin oligomers [19].
Negative_regulation (inhibition) of cholesterol in HeLa
4) Confidence 0.42 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0.12 Pain Relevance 0
Brain cholesterol deficiency and low abundance of desmosterol in 3-week-old DHCR24?
Negative_regulation (deficiency) of cholesterol in Brain
5) Confidence 0.42 Published 2008 Journal Neurochem Res Section Body Doc Link PMC2758381 Disease Relevance 0 Pain Relevance 0
The latter is a key intermediate in cholesterol synthesis and aids in decreasing LDL cholesterol and increasing HDL cholesterol levels [239, 240].
Negative_regulation (decreasing) of cholesterol associated with acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism
6) Confidence 0.42 Published 2010 Journal The Open Biochemistry Journal Section Body Doc Link PMC2864432 Disease Relevance 0.50 Pain Relevance 0
The results of the majority of the studies are coherent and indicate that the increased total cholesterol, LDL cholesterol and/or triglycerides, and decreased HDL cholesterol in psoriatic patients' serum the composition of apolipoproteins, and increased production of oxygen metabolites are features of the metabolic syndrome.
Negative_regulation (decreased) of cholesterol associated with psoriasis, metabolic syndrome and disorder of lipid metabolism
7) Confidence 0.42 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2914266 Disease Relevance 1.53 Pain Relevance 0.27
The non-selective COX inhibitor indomethacin also produced a significant reduction in cholesterol 27-hydroxylase and ABCA1 mRNA expression (50 ?
Negative_regulation (reduction) of cholesterol
8) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.06
When the CholAB – treated cultures were forced to differentiate (by removal of FGF2, CholAB, and the addition of B27 cell culture supplement and neurotrophins for 7 days), neurons, astrocytes, and oligodendrocytes were generated (Figure 5c), showing that the potential of the culture en masse to generate all three major lineages of neural tissue was not lost.
Negative_regulation (removal) of CholAB in neural
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2877108 Disease Relevance 0 Pain Relevance 0

General Comments

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