INT186624

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Context Info
Confidence 0.73
First Reported 2005
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.06
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Atp8a1)
Anatomy Link Frequency
immune cells 1
B cells 1
nucleus 1
internal 1
Atp8a1 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 5 98.36 Very High Very High Very High
Inflammation 11 61.84 Quite High
Potency 1 56.40 Quite High
potassium channel 1 55.88 Quite High
Inflammatory response 1 11.84 Low Low
Inflammatory mediators 1 10.88 Low Low
Chronic pancreatitis 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
medulla 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 19 93.00 High High
Targeted Disruption 13 85.68 High High
Glaucoma 2 80.32 Quite High
Ocular Hypertension 2 77.08 Quite High
Fungal Infection 1 74.08 Quite High
Thyroid Neoplasm 2 74.00 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 69.08 Quite High
Hypotension 1 68.72 Quite High
INFLAMMATION 13 61.84 Quite High
Celiac Disease 42 54.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These included genes encoding proteins involved in intracellular antigen processing and transport for eventual surface presentation to immune cells (PSMB8, TAP1), antigen presentation proteins, including HLA class I molecules (HLA-A, HLA-C, HLA-F, and HLA-G) and HLA class II molecules (HLA-DRB1, DRB4, DRB5, DPA1, and DPB1), cytokines involved in the recruitment of monocytes (SCYA3, SCYA4, CD14), and cytokine receptors (IL1R2, IL4R, and IL6R).
Localization (molecules) of class I in immune cells associated with cytokine
1) Confidence 0.73 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.30 Pain Relevance 0.12
To determine whether the remaining 161 peptides were indeed binders to the relevant HLA class I molecules, they were tested in a biochemical in vitro binding assay.
Localization (relevant) of class I
2) Confidence 0.73 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939062 Disease Relevance 0.18 Pain Relevance 0.03
While Class II HDACs are able to shuttle in and out of the nucleus, the Class III sirtuin family (SIRT1-7) has a different localization.
Localization (localization) of Class I in nucleus
3) Confidence 0.73 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.15 Pain Relevance 0.03
Specifically, we found significantly less MHC class I on the surface of B cells from BB-homozygotes compared to AA-homozygotes.
Localization (found) of class I in B cells
4) Confidence 0.68 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2954825 Disease Relevance 0.31 Pain Relevance 0
Confocal images show localization of both class1 and class2 on vessels structures (Figure 6A, B) and confirmed our finding that the two scFv classes have a distinct staining pattern, with class1 binding the more external layers and class2 the more internal layers.
Localization (localization) of class1 in internal
5) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837746 Disease Relevance 0.12 Pain Relevance 0.03

General Comments

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