INT186628

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 3.79
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

isomerase activity (DCT) cytosol (DCT) oxidoreductase activity (DCT)
cytoplasm (DCT)
Anatomy Link Frequency
skin 1
DCT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 55 92.64 High High
Immobilon 5 66.40 Quite High
metalloproteinase 11 42.20 Quite Low
COX-2 inhibitor 15 5.00 Very Low Very Low Very Low
Inflammatory mediators 11 5.00 Very Low Very Low Very Low
melanocortin 1 receptor 5 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Melanoma 220 100.00 Very High Very High Very High
Cancer 137 95.28 Very High Very High Very High
INFLAMMATION 61 92.64 High High
Stress 27 89.52 High High
Hypopigmentation 2 86.32 High High
Injury 5 86.00 High High
Pigment Disorder 2 85.36 High High
Ocular Albinism 1 81.84 Quite High
Metastasis 43 79.64 Quite High
Wound Healing 5 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UVB-induced PGE2 production does not correlate with melanin content, tyrosinase expression/activity or TRP-1 or DCT expression in EM
Gene_expression (expression) of DCT
1) Confidence 0.46 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.15 Pain Relevance 0.05
The current study suggests that while both AA- and UVB-induced PGE2 production by EM may be related to skin phototype of the EM donor, it is not correlated with EM melanin content, tyrosinase expression/activity or TRP-1 or DCT expression in vitro.
Gene_expression (expression) of DCT in skin
2) Confidence 0.46 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.22 Pain Relevance 0
No correlation was observed with baseline melanin content, baseline expression/activity of tyrosinase or baseline expression of TRP-1 or DCT (Figure 5).


Gene_expression (expression) of DCT
3) Confidence 0.41 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.18 Pain Relevance 0.04
By contrast, PGE2 production did not correlate with baseline melanin levels, tyrosinase expression/activity or TRP-1 or DCT expression.
Gene_expression (expression) of DCT
4) Confidence 0.36 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0.18 Pain Relevance 0.09
The basal expression of tyrosinase, TRP-1 and DCT was assessed in human EM extracts.
Gene_expression (expression) of DCT
5) Confidence 0.36 Published 2010 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2881306 Disease Relevance 0 Pain Relevance 0.03
Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a.
Gene_expression (expression) of DCT
6) Confidence 0.28 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794539 Disease Relevance 0.68 Pain Relevance 0
Global transcript profiling identified a signature featuring decreased expression of developmental and lineage specification genes including MITF, EDNRB, DCT, and TYR, and increased expression of genes involved in interaction with the extracellular environment, such as PLAUR, VCAN, and HIF1a.
Gene_expression (expression) of DCT
7) Confidence 0.28 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2794539 Disease Relevance 0.68 Pain Relevance 0
These genes encoded enzymes involved in melanogenesis, including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), as well as melanosomal matrix proteins such as SILV and MLANA.
Gene_expression (including) of dopachrome tautomerase
8) Confidence 0.16 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 1.39 Pain Relevance 0
DCT, CDK2, BCL2, GPR143) despite having relatively higher MITF expression (Figure 1B, C), indicating that there are probably melanoma sub-types present within the broad Motif 1 and 2 classifications, and that not all cell lines with lower MITF have a Motif 1 expression profile.


Gene_expression (expression) of DCT associated with melanoma
9) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.32 Pain Relevance 0

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