INT186629

Context Info Confidence 0.22 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.90 Pain Relevance 0.24

plasma membrane (HLA-F)

Anatomy Link Frequency immune cells 1 immune system 1 HLA-F (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 15 99.46 potassium channel 1 57.92 Inflammatory mediators 1 7.76 Inflammation 8 5.00 iatrogenic 4 5.00 chemokine 4 5.00 Neurotransmitter 3 5.00 Central nervous system 2 5.00 withdrawal 2 5.00 Neuritis 2 5.00

Disease Link Frequency Relevance Heat Viremia 2 86.24 Glaucoma 2 82.36 Infection 169 81.48 Disease 101 81.12 Ocular Hypertension 2 79.12 Hypergammaglobulinemia 1 74.48 Sarcoma 195 72.60 Hypotension 1 70.76 Acquired Immune Deficiency Syndrome Or Hiv Infection 113 50.16 Viral Infection 7 28.48

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These included genes encoding proteins involved in intracellular antigen processing and transport for eventual surface presentation to immune cells (PSMB8, TAP1), antigen presentation proteins, including HLA class I molecules (HLA-A, HLA-C, HLA-F, and HLA-G) and HLA class II molecules (HLA-DRB1, DRB4, DRB5, DPA1, and DPB1), cytokines involved in the recruitment of monocytes (SCYA3, SCYA4, CD14), and cytokine receptors (IL1R2, IL4R, and IL6R).

Gene_expression (molecules) of HLA-F in immune cells associated with cytokine

1) Confidence 0.22 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.31 Pain Relevance 0.12

These pathogenic effects can promote active changes in the infected human host, such as to increase cytokine production or to suppress MHC Class I (MHC I) presentation of viral proteins to the immune system.

Gene_expression (presentation) of MHC Class I in immune system associated with cytokine

2) Confidence 0.11 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.59 Pain Relevance 0.11

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