INT186632

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.28
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (TWIST1) DNA binding (TWIST1) transcription factor binding (TWIST1)
Anatomy Link Frequency
lymph node 1
embryo 1
cornea 1
acute muscle 1
TWIST1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 27 82.68 Quite High
metalloproteinase 2 79.12 Quite High
tolerance 2 43.80 Quite Low
Inflammation 7 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
palliative 4 5.00 Very Low Very Low Very Low
fibrosis 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 328 100.00 Very High Very High Very High
Prostate Cancer 159 100.00 Very High Very High Very High
Injury 13 99.18 Very High Very High Very High
Metastasis 65 99.02 Very High Very High Very High
Disease 95 98.20 Very High Very High Very High
Adenocarcinoma 3 97.36 Very High Very High Very High
Corneal Disease 4 91.76 High High
Breast Cancer 1 89.36 High High
Adhesions 3 84.00 Quite High
Cervical Cancer 2 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative PCR analysis showed up-regulation of TWIST1 in primary PCa samples and lymph node metastasis (P-value ?
Regulation (regulation) of TWIST1 in lymph node associated with prostate cancer and metastasis
1) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.34 Pain Relevance 0
Based on their recognized pathological functions and consistent deregulation in multiple PCa databases, twist homolog 1 (TWIST1), vav 3 guanine nucleotide exchange factor (VAV3) and dickkopf homolog 3 (DKK3) were selected for their potential role in the bypass of the AR pathway.
Regulation (deregulation) of twist homolog 1 associated with prostate cancer
2) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.04 Pain Relevance 0
Based on their recognized pathological functions and consistent deregulation in multiple PCa databases, twist homolog 1 (TWIST1), vav 3 guanine nucleotide exchange factor (VAV3) and dickkopf homolog 3 (DKK3) were selected for their potential role in the bypass of the AR pathway.
Regulation (deregulation) of TWIST1 associated with prostate cancer
3) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.04 Pain Relevance 0
Various genes normally expressed in the early embryo have been implicated in the control of the EMT triggered during tumor progression, including Twist, Snail, Slug, Goosecoid, and SIP1 [36, 37].
Regulation (control) of Twist in embryo associated with cancer
4) Confidence 0.13 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840411 Disease Relevance 0.85 Pain Relevance 0
An intriguing subset of genes in the cornea signature has been studied in tumor metastasis models because these genes encode proteins that regulate cell-cell or cell-matrix interactions (TWIST, MMP10, SERPINB5, THBS1, CEACAM1, C4.4A).
Regulation (regulate) of TWIST in cornea associated with metastasis
5) Confidence 0.09 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.92 Pain Relevance 0.07
in response to acute muscle injury suggesting that IL-6 may play a role in regulating SCs.
Regulation (regulating) of SCs in acute muscle associated with injury
6) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696599 Disease Relevance 0.10 Pain Relevance 0.07

General Comments

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