INT186637

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.02
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA4) ATPase activity (ABCA4) plasma membrane (ABCA4)
transmembrane transport (ABCA4)
Anatomy Link Frequency
fat 1
photoreceptor cells 1
ABCA4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 2 83.52 Quite High
Neurotransmitter 3 54.04 Quite High
Dopamine 1 42.40 Quite Low
Central nervous system 2 29.60 Quite Low
Neuritis 2 12.36 Low Low
Inflammation 8 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 74 99.84 Very High Very High Very High
Retina Disease 26 94.48 High High
Disease 102 93.12 High High
Rod Or Cone Dystrophy 3 92.56 High High
Obesity 12 82.96 Quite High
Ocular Toxicity (including Many Sub-types) 15 79.32 Quite High
Stress 16 73.60 Quite High
Targeted Disruption 9 63.84 Quite High
Nicotine Addiction 2 62.56 Quite High
Eye Disease 3 62.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The high level of ABCA4 polymorphism across individuals makes it difficult to determine any responsibility for ABCA4 in AMD [21]; however, its involvement is possible in a small number of cases [107].
Spec (determine) Regulation (responsibility) of ABCA4 associated with age-related macular degeneration
1) Confidence 0.37 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.08 Pain Relevance 0
The most notable of these, ABCA4, is involved in vitamin A transport in photoreceptor cells; mutations in the gene encoding ABCA4 can result in a spectrum of retinopathies, including retinitis pigmentosa, Stargardt's disease, cone-rod dystrophy, and ARMD.
Regulation (involved) of ABCA4 in photoreceptor cells associated with rod or cone dystrophy, age-related macular degeneration, disease and retina disease
2) Confidence 0.21 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.65 Pain Relevance 0.07
However, after correcting for changes in FFM and fat mass, 24-h EE was still lowered by CR or CREX, suggesting that energy deficit rather than caloric restriction per se caused the increase in energy efficiency.
Regulation (changes) of FFM in fat
3) Confidence 0.08 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.29 Pain Relevance 0

General Comments

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