INT186639

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.91
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (SLC11A2) nucleus (SLC11A2) vacuole (SLC11A2)
transmembrane transport (SLC11A2) lysosome (SLC11A2) cytoplasm (SLC11A2)
Anatomy Link Frequency
goblet cells 2
SLC11A2 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 2 42.20 Quite Low
Inflammation 28 35.72 Quite Low
cINOD 10 5.00 Very Low Very Low Very Low
aspirin 8 5.00 Very Low Very Low Very Low
nud 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Thalassemia 11 91.44 High High
Iron-deficiency Anemia 190 88.56 High High
Hypopigmentation 2 86.72 High High
Injury 6 86.00 High High
Pigment Disorder 2 85.76 High High
Ocular Albinism 1 82.24 Quite High
Metastasis 4 79.64 Quite High
Wound Healing 5 75.40 Quite High
Syndrome 11 73.52 Quite High
Stomach Cancer 1 73.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These genes encoded enzymes involved in melanogenesis, including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and dopachrome tautomerase (DCT), as well as melanosomal matrix proteins such as SILV and MLANA.
Gene_expression (including) of DCT
1) Confidence 0.65 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 1.40 Pain Relevance 0
Within the SLC11A2 gene, a heterozygous SNP (single nucleotide polymorphism) in intron 5 (IVS5+60 C>T) was detected.
Gene_expression (detected) of SLC11A2
2) Confidence 0.47 Published 2010 Journal Biochemical Journal Section Body Doc Link PMC2958558 Disease Relevance 0.09 Pain Relevance 0
DMT-1 is principally expressed in the enterocyte cytoplasm and lamina propria, but is also expressed in goblet cells and in the overlying mucous layer [11].
Gene_expression (expressed) of DMT-1 in goblet cells
3) Confidence 0.08 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 0.22 Pain Relevance 0
DMT-1 is principally expressed in the enterocyte cytoplasm and lamina propria, but is also expressed in goblet cells and in the overlying mucous layer [11].
Gene_expression (expressed) of DMT-1 in goblet cells
4) Confidence 0.08 Published 2010 Journal Dig Dis Sci Section Body Doc Link PMC2822907 Disease Relevance 0.21 Pain Relevance 0

General Comments

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