INT186663

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Context Info
Confidence 0.60
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.39
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PSMB9) nucleoplasm (PSMB9) peptidase activity (PSMB9)
small molecule metabolic process (PSMB9) nucleus (PSMB9) cellular nitrogen compound metabolic process (PSMB9)
Anatomy Link Frequency
lens 1
PSMB9 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 30 61.52 Quite High
Infliximab 22 50.00 Quite Low
methotrexate 17 21.24 Low Low
Inflammation 7 20.96 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
metalloproteinase 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
Etanercept 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 4 96.96 Very High Very High Very High
Shock 2 86.96 High High
Hepatitis 1 65.92 Quite High
Rheumatoid Arthritis 30 61.52 Quite High
Blindness 1 44.64 Quite Low
Cataract 3 43.12 Quite Low
Death 4 24.60 Low Low
INFLAMMATION 8 20.96 Low Low
Eye Disease 3 14.76 Low Low
Stress 2 9.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-dependent pathway in the control of translation; cell adhesion and inhibition of cell migration/invasion (LAMR1, MUCDHL, MTCPB1); cytochromes (CYP3A4, CYP4F12) and cytochrome oxidase (COX7A2L); proteasome-mediated proteolysis (FBXO5, PSMB9); various enzymes (AADAT, PFKFB4); intra- or extracellular signalling (AKAP9, CXCL5, PTPN12, RASGRP3, TBL2, THRAP3), including regulators of the ERK pathway (EPS15, SCAM-1); and innate or adaptive immunity (KNG1, MCP, PSMB9, HLA-DPB1).
Protein_catabolism (proteolysis) of PSMB9 associated with adhesions
1) Confidence 0.60 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779405 Disease Relevance 0.22 Pain Relevance 0.03
The lens signature also included genes encoding subunits of the proteasome complex (PSMA6, PSMA7, PSMB6, PSMB7, PSMB9, PSMD13), a multicatalytic proteinase structure that is responsible for degrading intracellular proteins.
Protein_catabolism (degrading) of PSMB9 in lens
2) Confidence 0.36 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.17 Pain Relevance 0

General Comments

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