INT186664

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Context Info
Confidence 0.16
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRB4) signal transduction (HLA-DRB4) Golgi apparatus (HLA-DRB4)
endoplasmic reticulum (HLA-DRB4) plasma membrane (HLA-DRB4)
Anatomy Link Frequency
immune cells 1
HLA-DRB4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 99.00 Very High Very High Very High
potassium channel 1 55.52 Quite High
Inflammatory mediators 1 12.16 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
cva 4 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Neuritis 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Glutamate 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dengue Hemorrhagic Fever 139 96.48 Very High Very High Very High
Infection 42 88.64 High High
Dengue 21 88.00 High High
Hepatitis B Virus Infection 1 87.32 High High
Hepatitis 2 86.80 High High
Hepatitis C Virus Infection 2 86.16 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 85.16 High High
Glaucoma 2 79.96 Quite High
Ocular Hypertension 2 76.72 Quite High
Hypotension 1 68.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Possibly there is a common primary associated gene closely located to DRB1 locus, such as HLA-DQB1 and HLA-DRB4, for those alleles (DRB1*07 and DRB1*04) and Vietnamese DRB1*0901.
Localization (located) of DRB4
1) Confidence 0.16 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2553281 Disease Relevance 1.59 Pain Relevance 0
These included genes encoding proteins involved in intracellular antigen processing and transport for eventual surface presentation to immune cells (PSMB8, TAP1), antigen presentation proteins, including HLA class I molecules (HLA-A, HLA-C, HLA-F, and HLA-G) and HLA class II molecules (HLA-DRB1, DRB4, DRB5, DPA1, and DPB1), cytokines involved in the recruitment of monocytes (SCYA3, SCYA4, CD14), and cytokine receptors (IL1R2, IL4R, and IL6R).
Localization (molecules) of DRB4 in immune cells associated with cytokine
2) Confidence 0.16 Published 2005 Journal Genome Biol Section Body Doc Link PMC1242209 Disease Relevance 0.30 Pain Relevance 0.13

General Comments

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