INT186677

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Context Info
Confidence 0.33
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.49
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTH) extracellular region (PTH) cell-cell signaling (PTH)
PTH (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuropathic pain 4 82.92 Quite High
Pain 2 81.72 Quite High
Sciatic nerve 1 65.60 Quite High
cytokine 23 53.48 Quite High
antagonist 2 7.92 Low Low
Inflammation 6 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 11 99.32 Very High Very High Very High
Chronic Hepatitis 23 93.52 High High
Osteoporosis 22 87.16 High High
Cirrhosis 10 86.04 High High
Neuropathic Pain 4 82.92 Quite High
Pain 2 81.72 Quite High
Nervous System Injury 1 65.88 Quite High
Nociception 2 62.16 Quite High
Stress 2 49.28 Quite Low
Anxiety Disorder 1 42.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the ECD of PTH1R has been crystallized in complex with PTH it is possible to construct a model which captures both the binding of the C-terminal part of the hormone to the ECD and its interactions with the transmembrane region of the receptor.
Protein_catabolism (crystallized) of PTH
1) Confidence 0.33 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2991341 Disease Relevance 0.47 Pain Relevance 0.32
Another report showed that the increase in bone resorption might be the result of decreased PTH degradation [41].
Protein_catabolism (degradation) of PTH associated with hypercalcemia
2) Confidence 0.26 Published 2005 Journal BMC Gastroenterol Section Body Doc Link PMC1242225 Disease Relevance 1.02 Pain Relevance 0.05

General Comments

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