INT186686

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.35
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (EDNRA) signal transduction (EDNRA) aging (EDNRA)
plasma membrane (EDNRA) signal transducer activity (EDNRA)
Anatomy Link Frequency
plasma 2
EDNRA (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 4 96.24 Very High Very High Very High
qutenza 40 86.48 High High
cytokine 4 79.32 Quite High
Inflammation 12 78.96 Quite High
ischemia 3 75.48 Quite High
metalloproteinase 1 63.68 Quite High
antagonist 24 55.60 Quite High
dorsal root ganglion 22 13.20 Low Low
peripheral neuropathy 2 9.44 Low Low
bradykinin 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 4 99.80 Very High Very High Very High
Diabetes Mellitus 55 98.88 Very High Very High Very High
Vascular Disease 1 97.72 Very High Very High Very High
Fibrosis 5 96.24 Very High Very High Very High
Endometriosis (extended) 2 94.08 High High
Systemic Sclerosis 6 87.76 High High
Peripheral Arterial Disease 5 82.48 Quite High
Hypertrophy 3 79.56 Quite High
INFLAMMATION 12 78.96 Quite High
Cv Unclassified Under Development 3 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, late treatment, 2 weeks after initiation of hypoxia, did not affect the established elevation of ET-1 level.


Regulation (affect) of Positive_regulation (elevation) of ET associated with hypoxia
1) Confidence 0.22 Published 2008 Journal European Heart Journal Section Body Doc Link PMC2515885 Disease Relevance 0.77 Pain Relevance 0.11
The results suggest that ET-1, through activation of the ETA receptor, is of importance for the regulation of the microcirculation in diabetic patients with micro-angiopathy.
Regulation (regulation) of Positive_regulation (activation) of ETA associated with vascular disease and diabetes mellitus
2) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605330 Disease Relevance 0.97 Pain Relevance 0.04
We therefore tested the effects of ETAR activation on the TRPV1 mutant TRPV1-S800A.
Regulation (effects) of Positive_regulation (activation) of ETAR
3) Confidence 0.15 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0 Pain Relevance 0.29
C1S, a third serine protease and activator of complement pathway is involved in activation of G-protein-coupled receptor pathway and contains a calcium-binding EGF domain.
Regulation (involved) of Positive_regulation (activation) of G-protein-coupled receptor
4) Confidence 0.02 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2519092 Disease Relevance 0.33 Pain Relevance 0.08
Upon these observations we believed that possible reason for higher plasma ET levels of osteoporotic men then the normal men in our study may be because of the lower bioavaliable estrogen concentration of the males in these ages and as a result possible decrease of estrogens effect in down regulation in ET and consequently increase of ET amount and effects.
Regulation (regulation) of Positive_regulation (increase) of ET in plasma
5) Confidence 0.02 Published 2005 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1242236 Disease Relevance 0.28 Pain Relevance 0

General Comments

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