INT1867

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Context Info
Confidence 0.69
First Reported 1975
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 0.55
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1)
cytoplasm (GABBR1) signal transducer activity (GABBR1)
Anatomy Link Frequency
dendrites 1
muscle 1
GABBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABA receptor 4 100.00 Very High Very High Very High
gABA 11 99.38 Very High Very High Very High
Locus ceruleus 4 99.32 Very High Very High Very High
Neurotransmitter 2 99.28 Very High Very High Very High
Cannabinoid receptor 1 98.18 Very High Very High Very High
substance P 1 95.64 Very High Very High Very High
Dopamine 3 93.72 High High
Spinal cord 8 82.16 Quite High
Clonidine 2 80.16 Quite High
Catecholamine 2 75.00 Quite High
Disease Link Frequency Relevance Heat
Muscle Hypertonia 1 96.32 Very High Very High Very High
Babinski Reflex 1 94.48 High High
Sleep Disorders 4 85.68 High High
Spasticity 31 77.68 Quite High
Overdose 3 73.68 Quite High
Stress 2 61.68 Quite High
Opiate Addiction 24 50.00 Quite Low
Pain 3 38.84 Quite Low
Muscular Spasm 1 38.48 Quite Low
Pruritus 2 36.16 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For various reasons it is speculated that an increased GABA receptor activity on the DA cell bodies and their dendrites could mainly be involved in causing the reduction of DA turnover observed after benzodiazepines by diminishing the firing rate in the ascending DA pathways, particularly the mesolimbic DA pathways.
Positive_regulation (increased) of GABA receptor in dendrites associated with gaba receptor
1) Confidence 0.69 Published 1975 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 242202 Disease Relevance 0 Pain Relevance 0.25
It is also suggested that the reduction of cortical NE turnover found after benzodiazepines can partly involve an increased GABA receptor activity on the locus ceruleus cells, although the activation of E receptors on these cells cannot be excluded.
Positive_regulation (increased) of GABA receptor associated with locus ceruleus and gaba receptor
2) Confidence 0.69 Published 1975 Journal Adv. Biochem. Psychopharmacol. Section Abstract Doc Link 242202 Disease Relevance 0.15 Pain Relevance 0.43
In heterodimeric GABAB receptors, GABABR1 binds the ligand while GABABR2 couples to the G protein and is required for targeting GABABR1 to the membrane (Brauner-Osborne et al., 2007).
Positive_regulation (targeting) of GABABR1
3) Confidence 0.49 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2906217 Disease Relevance 0 Pain Relevance 0
In heterodimeric GABAB receptors, GABABR1 binds the ligand while GABABR2 couples to the G protein and is required for targeting GABABR1 to the membrane (Brauner-Osborne et al., 2007).
Positive_regulation (required) of GABABR1
4) Confidence 0.49 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2906217 Disease Relevance 0 Pain Relevance 0
For example, the GABAB receptor assembly is mediated by short (~30 aa) parallel coiled-coil alpha helices in the C-terminal of the GABABR1 and GABABR2 receptors [24].
Positive_regulation (mediated) of GABAB receptor
5) Confidence 0.29 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC184451 Disease Relevance 0 Pain Relevance 0
Baclofen is a structural analog of the inhibitory neurotransmitter GABA, and may exert its effects by stimulation of the GABAB receptor to cause muscle relaxation.
Positive_regulation (stimulation) of GABAB receptor in muscle associated with gaba and neurotransmitter
6) Confidence 0.13 Published 2004 Journal BMC Clin Pharmacol Section Body Doc Link PMC514562 Disease Relevance 0.41 Pain Relevance 0.45
The EDG and cannabinoid receptors constitute clusters, and one cluster distinct from the other three consists of the orphan receptors GPR3, GPR6 and GPRC, which have been grouped closer to the lipid EDG receptors in the overall neighbor-joining tree (Figure 2).
Positive_regulation (receptors) of GPRC associated with cannabinoid receptor
7) Confidence 0.05 Published 2002 Journal Genome Biol Section Body Doc Link PMC133447 Disease Relevance 0 Pain Relevance 0.05

General Comments

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