INT18670

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Context Info
Confidence 0.54
First Reported 1982
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 16
Total Number 17
Disease Relevance 5.80
Pain Relevance 3.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
erythrocyte 1
muscle 1
THP-1 1
acinar cells 1
pancreatic ducts 1
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Endocannabinoid 18 100.00 Very High Very High Very High
antagonist 4 99.96 Very High Very High Very High
COX-2 inhibitor 78 99.80 Very High Very High Very High
agonist 10 99.60 Very High Very High Very High
lidocaine 2 99.32 Very High Very High Very High
Inflammation 67 98.08 Very High Very High Very High
Calcitonin gene-related peptide 7 97.94 Very High Very High Very High
Cannabinoid 14 96.32 Very High Very High Very High
tolerance 12 96.00 Very High Very High Very High
qutenza 4 90.20 High High
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 129 99.92 Very High Very High Very High
Injury 2 99.88 Very High Very High Very High
Adenocarcinoma 134 99.86 Very High Very High Very High
Disorder Of Lipid Metabolism 13 99.44 Very High Very High Very High
INFLAMMATION 79 98.08 Very High Very High Very High
Hemolysis 4 96.96 Very High Very High Very High
Necrosis 1 92.84 High High
Disease 95 91.68 High High
Pancreatic Cancer 54 89.00 High High
Islet Cell Adenoma 58 86.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
THP-1 macrophages exposed to the selective COX-2 inhibitor NS398 showed a dose-dependent decrease in ABCA1 protein level (Figure 7).
Negative_regulation (decrease) of ABCA1 protein in THP-1 associated with cox-2 inhibitor
1) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.15
TXA2 failed to reverse COX-2 inhibitor-mediated downregulation of 27-hydroxylase and ABCA1
Negative_regulation (downregulation) of ABCA1 associated with cox-2 inhibitor
2) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.17
COX-2 inhibitor-mediated downregulation of 27-hydroxylase and ABCA1 mRNA is reversed by prostaglandins PGE1, PGE2, and PGD2
Negative_regulation (downregulation) of ABCA1 mRNA associated with cox-2 inhibitor
3) Confidence 0.54 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.14
Reduction in ABCA1 combined with reduction in 27-hydroxylase as a result of COX inhibition could create a microenvironment within the vessel wall where cholesterol efflux is compromised.
Negative_regulation (Reduction) of ABCA1
4) Confidence 0.47 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.29 Pain Relevance 0.12
The selective COX-2 inhibitor N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide (NS398) significantly reduced 27-hydroxylase and ABCA1 message (to 62.4% ± 2.2% and 71.1% ± 3.9% of control, respectively).
Negative_regulation (reduced) of ABCA1 associated with cox-2 inhibitor
5) Confidence 0.40 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.33 Pain Relevance 0.15
The relative rate of hemolysis, which is well known to be a parameter accounting for the fluidity of erythrocyte membrane, decreases with increasing drug concentration, indicating a decrease in membrane fluidity.
Negative_regulation (decrease) of membrane in erythrocyte associated with hemolysis
6) Confidence 0.37 Published 1987 Journal Biomed. Biochim. Acta Section Abstract Doc Link 3579887 Disease Relevance 0.34 Pain Relevance 0.16
The non-selective COX inhibitor indomethacin also produced a significant reduction in cholesterol 27-hydroxylase and ABCA1 mRNA expression (50 ?
Negative_regulation (reduction) of ABCA1 mRNA
7) Confidence 0.17 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.06
These contribute to AMD by causing reduced Fibulin five and elastin production—a key Bruch's membrane component—but were not causal [129].
Negative_regulation (causing) of membrane associated with age-related macular degeneration
8) Confidence 0.13 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 1.32 Pain Relevance 0
The inhibition is due to partial phospholipid hydrolysis leading to inactivation of membrane-bound receptor. (2) Bee venom phospholipase A2 together with the synergistically acting peptide, melittin, causes receptor solubilization up to 80% of preformed receptor-ligand complex can be solubilized in this manner. (3) Lysophosphatidylcholine, a product of phospholipid hydrolysis, solubilizes performed receptor-ligand complex to a similar extent.
Negative_regulation (inactivation) of membrane-bound
9) Confidence 0.08 Published 1982 Journal Biochim. Biophys. Acta Section Abstract Doc Link 6279149 Disease Relevance 0 Pain Relevance 0.16
-catenin in pancreatic adenocarcinomas, with decreased plasma membrane and increased cytoplasmic staining compared to normal pancreatic ducts and acinar cells by immunohistochemistry [46].
Negative_regulation (decreased) of membrane in acinar cells associated with adenocarcinoma
10) Confidence 0.05 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.11 Pain Relevance 0
Several mechanisms, including depletion of sulfhydryl groups, reduced biotransformation of nitrates to NO or nitrosothiols, oxygen free radical injury, and downregulation of a membrane-bound enzyme or a nitrate receptor, have been proposed, but the exact mechanism responsible for in-vitro tolerance remains unknown.
Negative_regulation (downregulation) of membrane-bound associated with injury and tolerance
11) Confidence 0.03 Published 1997 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 9110117 Disease Relevance 0.41 Pain Relevance 0.44
-catenin in pancreatic adenocarcinomas, with decreased plasma membrane and increased cytoplasmic staining compared to normal pancreatic ducts and acinar cells by immunohistochemistry [46].
Negative_regulation (decreased) of membrane in pancreatic ducts associated with adenocarcinoma
12) Confidence 0.02 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1824711 Disease Relevance 1.11 Pain Relevance 0
As determined by depletion of membrane-bound [(3)H]phosphatidyl inositols, S18616 behaved as a (less potent) agonist (7.8/79%) at halpha(1A)-ARs, an action abolished by prazosin (pK(b), 8.9).
Spec (determined) Negative_regulation (depletion) of membrane-bound associated with agonist
13) Confidence 0.01 Published 2000 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 11082457 Disease Relevance 0.16 Pain Relevance 0.55
Membrane-bound CRegs (Fig. 1) include decay-accelerating factor (DAF, CD55), membrane co-factor protein (MCP, CD46), complement receptor 1 (CR1, CD35), and membrane inhibitor of reactive lysis (MIRL, CD59).
Negative_regulation (inhibitor) of membrane
14) Confidence 0.01 Published 2008 Journal Semin Immunopathol Section Body Doc Link PMC2315691 Disease Relevance 0 Pain Relevance 0
Thus, the present data suggest that the development of CGRP tachyphylaxis is a specific receptor-mediated event which can be inhibited by colchicine, probably by disruption of membrane bound proteins.
Negative_regulation (disruption) of membrane bound associated with calcitonin gene-related peptide
15) Confidence 0.01 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 2027526 Disease Relevance 0 Pain Relevance 0.55
The AChE inhibitors eserine and hexamethonium were competitive inhibitors of the membrane-bound enzyme, whereas lidocaine was a noncompetitive inhibitor; these results were comparable to the effect of these inhibitors on diaphragm muscle AChE.
Negative_regulation (inhibitors) of membrane-bound in muscle associated with lidocaine
16) Confidence 0.01 Published 1990 Journal J. Neurosci. Res. Section Abstract Doc Link 1979353 Disease Relevance 0 Pain Relevance 0.10
Data from animal model and human studies have suggested an upregulation of the ECS in inflammation processes either by increased receptor expression or by an enhancement of endocannabinoid production.[23]–[27] Treatment with CB1 agonists, FAAH antagonists, inhibitors of endocannabinoid membrane transport, or genetic ablation of FAAH reduced inflammation.[23], [25], [28] Additionally, cannabinoid CB2 agonists cause inhibition of proinflammatory citokines such as tumoral necrosis factor alfa (TNF?)
Negative_regulation (inhibitors) of membrane associated with endocannabinoid, necrosis, inflammation, cannabinoid, antagonist and agonist
17) Confidence 0.00 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2731878 Disease Relevance 0.73 Pain Relevance 0.64

General Comments

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