INT186701

Context Info Confidence 0.44 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.20

nucleoplasm (POLD4) nucleus (POLD4) nucleotidyltransferase activity (POLD4)

Anatomy Link Frequency CAR 1 POLD4 (Homo sapiens)

Pain Link Frequency Relevance Heat Somatostatin 2 99.46 nMDA receptor 4 99.00 spinal dorsal horn 38 70.68 adenocard 5 64.48 Inflammation 35 48.96 cytokine 3 19.52 Cholecystokinin 5 15.80 Calcitonin gene-related peptide 5 14.88 Neuropeptide 3 11.96 Opioid 3 10.60

Disease Link Frequency Relevance Heat Injury 5 57.84 INFLAMMATION 35 48.96 Nociception 20 5.00 Pain 10 5.00 Hypersensitivity 5 5.00 Hyperalgesia 4 5.00 Hypoalagesia 3 5.00 Urological Neuroanatomy 3 5.00 Generalized Anxiety Disorder 2 5.00 Congenital Anomalies 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Finally, two genes (NR2B subunit of NMDA receptor and SstR2 somatostatin receptor), while being up-regulated in both CAR-P3 and CAR-P12 groups relative to CONT group, showed significantly lower levels of expression (by 0.5 and 0.7 fold respectively) in CAR-P3 rats as compared to those in CAR-P12 animals (Table 1).

Regulation (regulated) of P12 in CAR associated with nmda receptor and somatostatin

1) Confidence 0.44 Published 2005 Journal Mol Pain Section Body Doc Link PMC1242251 Disease Relevance 0.06 Pain Relevance 0.20

General Comments

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