INT186714

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Context Info
Confidence 0.21
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 2.93
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxra) enzyme binding (Rxra) DNA binding (Rxra)
transcription factor binding (Rxra)
Rxra (Mus musculus)
Pain Term Frequency Confidence Heat
agonist 282 84.56 Quite High
Inflammatory response 30 76.48 Quite High
Inflammation 415 72.32 Quite High
cytokine 85 54.72 Quite High
fibrosis 17 40.44 Quite Low
corticosteroid 5 22.76 Low Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Acute Promyelocytic Leukemia 1 93.68 High High
Cancer 340 90.04 High High
Repression 11 85.60 High High
Brain Injury 116 85.52 High High
INFLAMMATION 464 76.48 Quite High
Immunotherapy Of Cancer 5 72.56 Quite High
Metabolic Disorder 1 71.60 Quite High
Osteogenic Sarcomas 80 68.92 Quite High
Gastrointestinal Neoplasms 16 67.20 Quite High
Thyroid Neoplasm 7 64.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The PPARs are one of the most studied RXR heterodimerization partners.Over 1000 papers have been published on the PPARs since their cloning in 1990 [1].Although some evidence suggests that the PPARs can form homodimers and bind to DNA response elements such as the Pal3 motif [2], it is widely accepted that the PPARs must heterodimerize with RXR to carry out most of their functions.
PPARs Binding (heterodimerize) of RXR
1) Confidence 0.21 Published 2009 Journal PPAR Research Section Body Doc Link PMC2801013 Disease Relevance 0 Pain Relevance 0
PPARs function as heterodimeric partners with RXR, and
PPARs Binding (partners) of RXR
2) Confidence 0.06 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430014 Disease Relevance 0.38 Pain Relevance 0.14
PPARs regulate gene transcription by heterodimerizing with the retinoid X receptor (RXR) and binding to specific consensus sequences (termed PPAR response elements, PPREs) in the enhancer regions of genes [6].
PPARs Binding (binding) of RXR
3) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.09 Pain Relevance 0
PPARs regulate gene transcription by heterodimerizing with the retinoid X receptor (RXR) and binding to specific consensus sequences (termed PPAR response elements, PPREs) in the enhancer regions of genes [6].
PPARs Binding (heterodimerizing) of RXR
4) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.09 Pain Relevance 0
PPARs regulate gene transcription by heterodimerizing with the retinoid X receptor (RXR) and binding to specific consensus sequences (termed PPAR response elements, PPREs) in the enhancer regions of genes [6].
PPARs Binding (binding) of retinoid X receptor
5) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.09 Pain Relevance 0
PPARs regulate gene transcription by heterodimerizing with the retinoid X receptor (RXR) and binding to specific consensus sequences (termed PPAR response elements, PPREs) in the enhancer regions of genes [6].
PPARs Binding (heterodimerizing) of retinoid X receptor
6) Confidence 0.06 Published 2010 Journal PPAR Research Section Body Doc Link PMC2748193 Disease Relevance 0.09 Pain Relevance 0
PPARs function as heterodimers with retinoid X receptor (RXR, NR2B), and their TF activity is regulated by the binding of ligands, the interactions with coregulators (both activator and repressor proteins), and DNA-binding sites [5].
PPARs Binding (heterodimers) of RXR
7) Confidence 0.04 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943117 Disease Relevance 0 Pain Relevance 0
In order to be transcriptionally active, PPARs need to heterodimerize with the retinoid-X-receptor (RXR).
PPARs Binding (heterodimerize) of retinoid-X-receptor
8) Confidence 0.04 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.32 Pain Relevance 0.16
PPARs requires heterodimerization with the retinoid X receptor (RXR), and
PPARs Binding (heterodimerization) of RXR
9) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.18 Pain Relevance 0.03
PPARs requires heterodimerization with the retinoid X receptor (RXR), and
PPARs Binding (heterodimerization) of retinoid X receptor
10) Confidence 0.03 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.18 Pain Relevance 0.03
The heterodimer between PPARs and RXR then binds to PPRE, resulting in stimulation of transcription.
PPARs Binding (heterodimer) of RXR
11) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.07 Pain Relevance 0
Transactivation of PPARs is a DNA-dependent mechanism, which involves binding of the PPAR ligands and heterodimerization between PPARs and RXR (Retinoid X receptor) [16].
PPARs Binding (heterodimerization) of RXR
12) Confidence 0.03 Published 2009 Journal PPAR Research Section Body Doc Link PMC2770108 Disease Relevance 0.06 Pain Relevance 0
Upon binding ligand, PPARs heterodimerize with the common retinoid X receptor (RXR, Issemann et al., 1993), and recruit coregulators and chromatin-modifying enzymes to specific DNA sequences, termed peroxisome proliferator response elements (PPREs), in the promoters of target genes (coregulator biology reviewed in McKenna and O'Malley, 2002).
PPARs Binding (heterodimerize) of RXR
13) Confidence 0.03 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2912024 Disease Relevance 0.23 Pain Relevance 0.03
Beyond the ability of RXR to heterodimerize with many members of the nuclear receptor superfamily, such as PPARs, RXRs can form homodimers.
PPARs Binding (heterodimerize) of RXR
14) Confidence 0.02 Published 2010 Journal PPAR Research Section Body Doc Link PMC2825651 Disease Relevance 0.89 Pain Relevance 0.06
PPARs heterodimerise with the 9-cis-retinoic acid receptors (RXR) and the resultant heterodimer subsequently binds to PPRE with the recruitment of cofactors.
PPARs Binding (heterodimerise) of RXR
15) Confidence 0.01 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.28 Pain Relevance 0.07

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