INT18672

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 3
Speculated 4
Reported most in Abstract
Documents 54
Total Number 60
Disease Relevance 36.64
Pain Relevance 18.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeletal protein binding (Ncam1) aging (Ncam1) cell adhesion (Ncam1)
plasma membrane (Ncam1)
Anatomy Link Frequency
neuronal 9
neural 8
medial 4
pancreatic ducts 3
neurons 3
Ncam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 1 100.00 Very High Very High Very High
fluoxetine 88 99.92 Very High Very High Very High
Somatostatin 1 99.86 Very High Very High Very High
Sciatic nerve 68 99.68 Very High Very High Very High
Serotonin 45 99.52 Very High Very High Very High
Inflammation 31 99.48 Very High Very High Very High
substance P 1 99.40 Very High Very High Very High
Neuropeptide 3 99.14 Very High Very High Very High
antidepressant 32 99.12 Very High Very High Very High
antagonist 15 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 136 100.00 Very High Very High Very High
Adhesions 74 100.00 Very High Very High Very High
Disease 21 100.00 Very High Very High Very High
Langerhans-cell Histiocytosis 6 100.00 Very High Very High Very High
Injury 100 99.88 Very High Very High Very High
Pancreatic Cancer 6 99.84 Very High Very High Very High
Primitive Neuroectodermal Tumors 76 99.76 Very High Very High Very High
INFLAMMATION 31 99.48 Very High Very High Very High
Depression 66 98.56 Very High Very High Very High
Cold Sores 1 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
PSA-NCAM expression in this system does not vary markedly in relation to different conditions of regulated neurosecretion, suggesting that the glycoprotein reaches cell surfaces via the constitutive pathway.
Gene_expression (expression) of NCAM
1) Confidence 0.78 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.34 Pain Relevance 0
We found that NCAM was expressed in intrinsic neurons in the spinal dorsal horn and in dorsal root ganglion neurons with small cell bodies.
Gene_expression (expressed) of NCAM in dorsal horn associated with ganglion cysts, spinal dorsal horn and root ganglion neuron
2) Confidence 0.77 Published 2008 Journal Pain Section Abstract Doc Link 17967506 Disease Relevance 1.04 Pain Relevance 1.11
As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity.
Gene_expression (expression) of PSA-NCAM in neuronal associated with antidepressant, depression and serotonin
3) Confidence 0.76 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.37 Pain Relevance 0.46
These results indicate that fluoxetine, acting through 5-HT3 receptors, can modulate PSA-NCAM expression in the mPFC.
Gene_expression (expression) of PSA-NCAM associated with fluoxetine
4) Confidence 0.76 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.17 Pain Relevance 0.71
Chronic fluoxetine treatment increases the expression of PSA-NCAM in the medial prefrontal cortex.
Gene_expression (expression) of PSA-NCAM in medial associated with fluoxetine
5) Confidence 0.76 Published 2007 Journal Neuropsychopharmacology Section Title Doc Link 16900104 Disease Relevance 0.35 Pain Relevance 0.50
The effects of fluoxetine treatment for 14 days on mPFC PSA-NCAM expression have also been analyzed.
Gene_expression (expression) of PSA-NCAM associated with fluoxetine
6) Confidence 0.76 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.30 Pain Relevance 0.72
As the expression of PSA-NCAM is increased by serotonin in other cerebral regions, antidepressants acting on serotonin reuptake may influence PSA-NCAM expression and thus counteract the effects of depression by modulating neuronal structural plasticity.
Gene_expression (expression) of PSA-NCAM in neuronal associated with antidepressant, depression and serotonin
7) Confidence 0.76 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.36 Pain Relevance 0.53
This plasticity may be mediated by the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), which is intensely expressed in the adult mPFC.
Gene_expression (expressed) of PSA-NCAM in neural associated with adhesions
8) Confidence 0.76 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 16900104 Disease Relevance 0.37 Pain Relevance 0.44
We suggested that CD56 expression is degenerative process in pancreatic tissue with chronic inflammation, and that examination of CD56 expression may be helpful in the differentiation of atypical degenerative ducts from cancerous ducts.
Gene_expression (expression) of CD56 in ducts associated with inflammation
9) Confidence 0.74 Published 2006 Journal Kurume Med J Section Abstract Doc Link 17317933 Disease Relevance 0.91 Pain Relevance 0.26
CD56 expression was analyzed in 25 tissue samples of invasive ductal carcinoma without mixed ductal-endocrine carcinoma of the pancreas, and in the surrounding non-cancerous pancreatic tissue.
Spec (analyzed) Gene_expression (expression) of CD56 in pancreas associated with ductal carcinoma and carcinoma
10) Confidence 0.74 Published 2006 Journal Kurume Med J Section Abstract Doc Link 17317933 Disease Relevance 0.86 Pain Relevance 0.22
We suggested that CD56 expression is degenerative process in pancreatic tissue with chronic inflammation, and that examination of CD56 expression may be helpful in the differentiation of atypical degenerative ducts from cancerous ducts.
Gene_expression (expression) of CD56 in ducts associated with inflammation
11) Confidence 0.74 Published 2006 Journal Kurume Med J Section Abstract Doc Link 17317933 Disease Relevance 0.95 Pain Relevance 0.27
CD56 (NCAM) expression in pancreatic carcinoma and the surrounding pancreatic tissue.
Gene_expression (expression) of CD56 associated with pancreatic cancer
12) Confidence 0.74 Published 2006 Journal Kurume Med J Section Title Doc Link 17317933 Disease Relevance 0.89 Pain Relevance 0.23
Expression of CD56, also known as the neural cell adhesion molecule (NCAM), in the pancreatic ducts of chronic pancreatitis is considered to represent a regenerative process of the pancreatic duct system.
Gene_expression (Expression) of CD56 in pancreatic duct associated with chronic pancreatitis and adhesions
13) Confidence 0.74 Published 2006 Journal Kurume Med J Section Abstract Doc Link 17317933 Disease Relevance 0.60 Pain Relevance 0.13
CD56 expression was detected in intercalated ducts (ICDs) of lobules in the pancreatic parenchyma showing chronic inflammation close to the carcinoma, but not in the carcinoma itself, in all cases.
Gene_expression (expression) of CD56 in parenchyma associated with inflammation and carcinoma
14) Confidence 0.74 Published 2006 Journal Kurume Med J Section Abstract Doc Link 17317933 Disease Relevance 0.95 Pain Relevance 0.25
Chronic antidepressant treatment induces contrasting patterns of synaptophysin and PSA-NCAM expression in different regions of the adult rat telencephalon.
Gene_expression (expression) of PSA-NCAM in telencephalon associated with antidepressant
15) Confidence 0.72 Published 2007 Journal Eur Neuropsychopharmacol Section Title Doc Link 17307340 Disease Relevance 0.15 Pain Relevance 0.44
Chronic fluoxetine treatment increases synaptophysin and PSA-NCAM expression in the medial prefrontal cortex and decreases them in the amygdala.
Gene_expression (expression) of PSA-NCAM in medial associated with amygdala and fluoxetine
16) Confidence 0.72 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.18 Pain Relevance 0.47
In order to know whether chronic fluoxetine treatment induces differential neuronal structural plasticity in rats, we have analyzed the expression of synaptophysin, a protein considered a marker of synaptic density, and the expression of the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), a molecule involved in neurite and synaptic remodeling.
Spec (analyzed) Gene_expression (expression) of PSA-NCAM in neuronal associated with adhesions and fluoxetine
17) Confidence 0.72 Published 2007 Journal Eur Neuropsychopharmacol Section Abstract Doc Link 17307340 Disease Relevance 0.19 Pain Relevance 0.49
The authors hypothesize that CD56 expression in this patient might have contributed to her predisposition to EML.
Gene_expression (expression) of CD56 associated with leukemia
18) Confidence 0.70 Published 1997 Journal Am. J. Hematol. Section Abstract Doc Link 9257883 Disease Relevance 0.98 Pain Relevance 0.08
Furthermore, this patient had blast expression of the neural cell adhesion molecule (CD56), a cell surface marker that has not been studied in ALL but has previously been identified as a risk factor for extramedullary leukemia (EML) in acute non-lymphocytic leukemia.
Gene_expression (expression) of CD56 in neural associated with chronic lymphoid leukemia, leukemia and adhesions
19) Confidence 0.70 Published 1997 Journal Am. J. Hematol. Section Abstract Doc Link 9257883 Disease Relevance 1.26 Pain Relevance 0.09
To study this more directly, we here used immunofluorescence for PSA on NCAM in live, unpermeabilized cells to monitor PSA-NCAM surface expression in organotypic slice cultures from postnatal rat hypothalami.
Gene_expression (expression) of NCAM
20) Confidence 0.68 Published 2001 Journal Neuroscience Section Abstract Doc Link 11311794 Disease Relevance 0.30 Pain Relevance 0

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