INT186724

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.59
Pain Relevance 1.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (MMP9) extracellular space (MMP9) extracellular region (MMP9)
proteinaceous extracellular matrix (MMP9) extracellular matrix organization (MMP9) protein complex (MMP9)
MMP9 (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 206 100.00 Very High Very High Very High
agonist 27 99.70 Very High Very High Very High
anesthesia 6 88.72 High High
epidural 1 88.28 High High
Inflammation 52 79.56 Quite High
Inflammatory response 8 77.28 Quite High
addiction 12 72.32 Quite High
cytokine 23 66.60 Quite High
Pain 2 57.04 Quite High
Arthritis 8 54.64 Quite High
Disease Link Frequency Relevance Heat
Breast Cancer 56 98.92 Very High Very High Very High
Asthma 21 97.84 Very High Very High Very High
Fibrosarcoma 6 86.72 High High
Systemic Inflammatory Response Syndrome 22 81.12 Quite High
INFLAMMATION 57 79.56 Quite High
Apoptosis 17 79.36 Quite High
Airway Remodeling 2 78.52 Quite High
Carcinoma 1 75.92 Quite High
Metastasis 19 74.80 Quite High
Cancer 61 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We measured serum mRNA levels of 11 genes (MMP9, CRP, HMGB1, MUC1, EGR1, PBEF1, PDGFA, TGF-?
Negative_regulation (measured) of Transcription (levels) of MMP9
1) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.36 Pain Relevance 0.50
The most of marine saccharoid MMPIs inhibit MMP by direct down-regulation of MMP-9 transcription or via inhibition of activator protein-1(AP-1) pathway or nuclear factor ?
Negative_regulation (regulation) of Transcription (transcription) of MMP-9
2) Confidence 0.23 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0 Pain Relevance 0.07
Transfection studies carried out with MMP-9 and AP-1 reporter constructs suggested that the observed reduction in MMP-9 expression was due to down-regulation of MMP-9 transcription which mediated via inhibition of AP-1.
Negative_regulation (regulation) of Transcription (transcription) of MMP-9
3) Confidence 0.20 Published 2009 Journal Marine Drugs Section Body Doc Link PMC2707034 Disease Relevance 0.26 Pain Relevance 0.11
agonists, resulting in decreased MMP-9 mRNA expression [15].
Negative_regulation (decreased) of Transcription (expression) of MMP-9 associated with metalloproteinase and agonist
4) Confidence 0.10 Published 2005 Journal Respir Res Section Body Doc Link PMC1242255 Disease Relevance 0.58 Pain Relevance 0.45
We did observe very low MMP-9 mRNA expression in control Hs578T cells, which could account for these results.
Negative_regulation (low) of Transcription (expression) of MMP-9 associated with metalloproteinase
5) Confidence 0.07 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1559713 Disease Relevance 0.39 Pain Relevance 0.44

General Comments

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