INT18677

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 1985
Last Reported 2011
Negated 3
Speculated 1
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 30.86
Pain Relevance 5.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (F3) cytoplasm (F3)
Anatomy Link Frequency
monocytes 8
macrophages 3
platelets 2
blood 2
endothelial cells 2
F3 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 12 100.00 Very High Very High Very High
Nerve growth factor 1 100.00 Very High Very High Very High
Somatostatin 10 99.86 Very High Very High Very High
Angina 56 99.84 Very High Very High Very High
Inflammatory response 45 99.70 Very High Very High Very High
substance P 1 99.40 Very High Very High Very High
Inflammation 189 99.32 Very High Very High Very High
metalloproteinase 3 99.28 Very High Very High Very High
Neuropeptide 3 99.14 Very High Very High Very High
cytokine 121 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 258 100.00 Very High Very High Very High
Adhesions 32 100.00 Very High Very High Very High
Cv General 3 Under Development 56 99.84 Very High Very High Very High
Sepsis 258 99.74 Very High Very High Very High
Atherosclerosis 87 99.56 Very High Very High Very High
Stress 110 99.48 Very High Very High Very High
Myocardial Infarction 55 99.36 Very High Very High Very High
Heart Rate Under Development 54 99.24 Very High Very High Very High
Apoptosis 13 99.24 Very High Very High Very High
Coronary Heart Disease 11 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
100, BD Biosciences) [18], mouse anti-human tissue factor CD142:RPE and mouse anti-human CD42b:FITC or mouse anti-human CD38:FITC, alternatively mouse anti-human CD66:FITC, simultaneously or isotype controls IgG1:FITC and IgG1:PE (all from BD Biosciences).


Gene_expression (anti) of CD142
1) Confidence 0.65 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.07 Pain Relevance 0.05
Synthesis and labeling of 213Bi-DTPA-[F3]2 and 68Ga-DTPA-[F3]2
Gene_expression (Synthesis) of F3
2) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.70 Pain Relevance 0
DTPA-[F3]2 was synthesized by GenScript Corporation, Piscataway, NJ.
Gene_expression (synthesized) of F3
3) Confidence 0.59 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.68 Pain Relevance 0
Therefore, F3 may be an appropriate carrier for ?
Gene_expression (appropriate) of F3
4) Confidence 0.51 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682652 Disease Relevance 1.44 Pain Relevance 0
As F3 was shown to be internalized into the nucleus of tumor cells and therefore may be an appropriate carrier for ?
Gene_expression (shown) of F3 in nucleus associated with cancer
5) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.79 Pain Relevance 0
-particle emitting isotope 213Bi, DTPA-[F3]2 was synthesized which is a F3-dimer linked to DTPA.
Gene_expression (synthesized) of F3
6) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.65 Pain Relevance 0.14
Therefore, F3 may be an appropriate carrier for ?
Spec (may) Gene_expression (may) of F3
7) Confidence 0.51 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2682652 Disease Relevance 1.43 Pain Relevance 0
-particle emitting isotope 213Bi, DTPA-[F3]2 was synthesized which is a F3-dimer linked to DTPA.
Gene_expression (synthesized) of F3
8) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.65 Pain Relevance 0.14
Synthesis and labeling of 213Bi-DTPA-[F3]2 and 68Ga-DTPA-[F3]2
Gene_expression (Synthesis) of F3
9) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 0.70 Pain Relevance 0
In previous studies by Porkka et al. [14] FITC-F3 was also found in single cells in the intestine and in the skin, whereas in our study no relevant activities were found in these tissues.
Neg (no) Gene_expression (found) of F3 in skin
10) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682652 Disease Relevance 1.17 Pain Relevance 0
This, together with the fact that mCF3PP is known to produce several pharmacological effects compatible with a stimulatory action on 5-hydroxytryptamine postsynaptic receptors, suggests that this metabolite may contribute to the parent drug's pharmacological effects.
Gene_expression (produce) of mCF3PP
11) Confidence 0.19 Published 1985 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 2858538 Disease Relevance 0 Pain Relevance 0.08
Quantitative real time polymerase chain reaction with mRNA isolated from the aorta of each mouse revealed no significant changes in the expression of tissue factor and inducible nitric oxide synthase.
Gene_expression (expression) of tissue factor in aorta
12) Confidence 0.18 Published 2003 Journal Cardiovasc. Res. Section Body Doc Link 14522423 Disease Relevance 0.06 Pain Relevance 0
Formation of the tissue factor-factor VIIa complex leads to the generation of thrombin that can activate cells through cleavage of PAR-1.
Gene_expression (Formation) of tissue factor in cleavage
13) Confidence 0.12 Published 2007 Journal Hepatology Section Abstract Doc Link 17654741 Disease Relevance 0.52 Pain Relevance 0.07
Stx2 and EHEC-LPS induce tissue factor expression on platelet-leukocyte aggregates
Gene_expression (expression) of tissue factor in leukocyte
14) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.05 Pain Relevance 0
Activated platelets, monocytes and neutrophils release microparticles which express tissue factor (TF) [8], [9], [10].
Gene_expression (express) of tissue factor in neutrophils
15) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.93 Pain Relevance 0.16
Stx2 and EHEC-LPS induce platelet-monocyte aggregate formation and tissue factor expression under shear stress
Gene_expression (expression) of tissue factor in monocyte associated with stress
16) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.10 Pain Relevance 0.08
30, BD Biosciences) to detect tissue factor, mouse anti-human CD42b:RPE-Cy5 and mouse anti-human CD38:FITC or mouse anti-human CD66:FITC or their respective control antibodies.
Gene_expression (detect) of tissue factor
17) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.16 Pain Relevance 0.04
100, BD Biosciences) [18], mouse anti-human tissue factor CD142:RPE and mouse anti-human CD42b:FITC or mouse anti-human CD38:FITC, alternatively mouse anti-human CD66:FITC, simultaneously or isotype controls IgG1:FITC and IgG1:PE (all from BD Biosciences).


Gene_expression (anti) of tissue factor
18) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2735777 Disease Relevance 0.12 Pain Relevance 0.05
On the left hand aromatic ring of the structure, substitution in both the ortho and meta positions with either halogen or CF3 groups was a definite requirement for potency.
Gene_expression (positions) of CF3 associated with potency
19) Confidence 0.11 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0 Pain Relevance 0.25
These properties include an inward (depolarizing) current with a conductance increase in response to activation of a bradykinin receptor, an inward (depolarizing) current with a conductance increase in response to the sensory excitotoxin capsaicin, the expression of sensory neuropeptides (substance P, CGRP and somatostatin), the expression of phosphatidylinositol-anchored molecules including adhesion molecules of the immunoglobulin superfamily that can be regulated in serum-free culture by nerve growth factor (N-CAM, F-3 and Thy-1), and low permissivity to herpes simplex virus infection.
Gene_expression (expression) of F-3 in nerve associated with qutenza, somatostatin, bradykinin, nerve growth factor, cold sores, neuropeptide, substance p and adhesions
20) Confidence 0.10 Published 1990 Journal Proc. Biol. Sci. Section Abstract Doc Link 1979443 Disease Relevance 0.44 Pain Relevance 0.47

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox