INT186786

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Context Info
Confidence 0.50
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 4.81
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NRIP1)
Anatomy Link Frequency
fat 1
WAT 1
NRIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 94 90.00 High High
pain pelvic 2 70.00 Quite High
tolerance 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
behavioral therapy 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 375 100.00 Very High Very High Very High
Endometriosis 104 90.00 High High
Targeted Disruption 29 89.20 High High
Embryo Loss 2 82.72 Quite High
Reprotox - General 3 8 82.40 Quite High
Syndrome 10 78.44 Quite High
Disease 25 69.04 Quite High
Weight Loss 6 52.48 Quite High
Male Infertility 4 5.00 Very Low Very Low Very Low
Impaired Glucose Tolerance 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Targeting disruption experiments of this function in mice have demonstrated that nuclear receptor interacting protein 1 (nrip1) gene (GenBank NM_173440), the gene encoding for rip140 protein, is essential for female fertility [3].
Positive_regulation (essential) of nrip1
1) Confidence 0.50 Published 2005 Journal J Exp Clin Assist Reprod Section Body Doc Link PMC1242355 Disease Relevance 1.08 Pain Relevance 0.21
More recently, a role for nrip1 gene in fat accumulation has been also proposed [6].
Positive_regulation (role) of nrip1 in fat
2) Confidence 0.50 Published 2005 Journal J Exp Clin Assist Reprod Section Body Doc Link PMC1242355 Disease Relevance 0.82 Pain Relevance 0.21
RIP140 mRNA levels in subcutaneous WAT were decreased among obese compared to lean women and increased by weight-loss, but did not associate with mitochondrial DNA copy number.
Positive_regulation (increased) of RIP140 mRNA in WAT associated with obesity
3) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 1.26 Pain Relevance 0
We therefore consider the alternative that the physiological role of increased levels of RIP140 in lean subjects functions to economize on energy stores more likely.
Positive_regulation (increased) of RIP140
4) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.63 Pain Relevance 0
Increased levels of human RIP140 in subcutaneous WAT of lean subjects may contribute to economize on energy stores.
Positive_regulation (Increased) of RIP140 associated with obesity
5) Confidence 0.47 Published 2010 Journal BMC Endocr Disord Section Abstract Doc Link PMC2825205 Disease Relevance 1.01 Pain Relevance 0

General Comments

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