INT186790

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Context Info
Confidence 0.45
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 6.68
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (NRIP1)
Anatomy Link Frequency
adipocyte 2
fat 1
NRIP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 141 98.88 Very High Very High Very High
pain pelvic 3 85.04 High High
tolerance 5 51.04 Quite High
anesthesia 5 5.00 Very Low Very Low Very Low
behavioral therapy 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 625 100.00 Very High Very High Very High
Endometriosis 156 98.88 Very High Very High Very High
Embryo Loss 3 97.76 Very High Very High Very High
Syndrome 15 91.84 High High
Reprotox - General 3 12 85.68 High High
Disease 38 84.08 Quite High
Targeted Disruption 48 74.16 Quite High
Weight Loss 10 61.68 Quite High
Death 5 57.44 Quite High
Impaired Glucose Tolerance 5 51.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In our study we found no association between RIP140 mRNA levels and mtDNA copy number, which is in agreement with a study performed in mice [4].
Neg (no) Regulation (association) of RIP140 mRNA
1) Confidence 0.45 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.71 Pain Relevance 0
However, the function and expression of RIP140 mRNA in human subcutaneous WAT, which comprises the main store of body fat, has to our knowledge not been reported.
Regulation (reported) of RIP140 mRNA in fat associated with obesity
2) Confidence 0.45 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.11 Pain Relevance 0.03
Following this working hypothesis, targeting disruption of nuclear receptors and their regulators such as nrip1 or CCR4-NOT transcription complex, subunit 7 (cnot7 GenBank AK009561) in animal models have provided direct evidence of the importance of nuclear receptor homeostasis in male and female reproduction [3,21-24].
Regulation (regulators) of nrip1
3) Confidence 0.45 Published 2005 Journal J Exp Clin Assist Reprod Section Body Doc Link PMC1242355 Disease Relevance 0.51 Pain Relevance 0.19
During in vitro human adipocyte differentiation RIP140 levels were up-regulated during the 8th and 12th day compared to the 4th day of differentiation (P < 0.001 for both).
Regulation (regulated) of RIP140 in adipocyte
4) Confidence 0.39 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 1.04 Pain Relevance 0
Role of Receptor-Interacting Protein 140 in human fat cells

Background

Regulation (Role) of Receptor-Interacting Protein 140 in fat cells associated with obesity
5) Confidence 0.27 Published 2010 Journal BMC Endocr Disord Section Title Doc Link PMC2825205 Disease Relevance 1.08 Pain Relevance 0
On the other hand, down regulation of RIP140 in obesity could be accompanied by changes in expression of other transcription factors and co-factors, which could lead to a different metabolic outcome than down regulation of RIP140 in cell cultures.


Regulation (regulation) of RIP140 associated with obesity
6) Confidence 0.27 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2825205 Disease Relevance 0.49 Pain Relevance 0
Receptor Interacting Protein 140 (RIP140) (Swiss-Prot P48552) is a high pleiotropic protein that acts as a co-regulator of multiple members of the nuclear receptor super-family including oestrogen, progesterone, retinoid acid or glucocorticoid receptors.
Regulation (acts) of RIP140
7) Confidence 0.27 Published 2005 Journal J Exp Clin Assist Reprod Section Body Doc Link PMC1242355 Disease Relevance 0.86 Pain Relevance 0.21
Receptor Interacting Protein 140 (RIP140) (Swiss-Prot P48552) is a high pleiotropic protein that acts as a co-regulator of multiple members of the nuclear receptor super-family including oestrogen, progesterone, retinoid acid or glucocorticoid receptors.
Regulation (acts) of Receptor Interacting Protein 140
8) Confidence 0.23 Published 2005 Journal J Exp Clin Assist Reprod Section Body Doc Link PMC1242355 Disease Relevance 0.87 Pain Relevance 0.21

General Comments

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