INT186797

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Context Info
Confidence 0.70
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.69
Pain Relevance 0.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
Anatomy Link Frequency
nasal 1
epithelium 1
TLR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 63 95.56 Very High Very High Very High
Inflammation 56 39.00 Quite Low
cytokine 26 5.00 Very Low Very Low Very Low
Antihistamine 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
pain pelvic 3 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometrial Cancer 12 100.00 Very High Very High Very High
Hyperplasia 9 100.00 Very High Very High Very High
Endometriosis (extended) 114 99.96 Very High Very High Very High
Carcinoma 24 99.72 Very High Very High Very High
Adenocarcinoma 21 89.16 High High
Rhinitis 25 82.76 Quite High
Malignant Neoplastic Disease 6 80.00 Quite High
Endometriosis 36 56.20 Quite High
INFLAMMATION 56 39.00 Quite Low
Uterine Diseases 15 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR3 and TLR4 mRNA abundance in healthy postmenopausal tissues is similar to those found during the menstrual cycle.
Localization (abundance) of TLR3
1) Confidence 0.70 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.67 Pain Relevance 0.08
TLR3 and TLR4 proteins in hyperplasia and endometrial carcinoma were mostly localized to the luminal and glandular epithelium (figure 6).
Localization (localized) of TLR3 in epithelium associated with endometrial cancer and hyperplasia
2) Confidence 0.70 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.00 Pain Relevance 0.03
First of all, we must acknowledge that TLR2, TLR3 and TLR4 appear to be localized mainly in the apical part of the epithelium. mRNA from nasal biopsies is comprised of a heterogeneous mix of different cells not only from the epithelium, but also from the submucosa.
Localization (localized) of TLR3 in nasal
3) Confidence 0.62 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.08 Pain Relevance 0
In undifferentiated G3 carcinoma, staining for TLR3 (figure 6E) and TLR4 (figure 6J) was not detectable, strengthening our findings of low TLR3 and TLR4 mRNA abundance in G3 carcinoma (figure 5B).
Localization (abundance) of TLR3 associated with carcinoma
4) Confidence 0.31 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.94 Pain Relevance 0

General Comments

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