INT186798

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.13
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
Anatomy Link Frequency
endometrium 1
nasal mucosa 1
TLR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 42 99.40 Very High Very High Very High
Inflammation 61 94.96 High High
cytokine 37 89.20 High High
chemokine 20 87.36 High High
agonist 9 86.88 High High
tolerance 3 77.52 Quite High
Inflammatory response 4 29.68 Quite Low
Arthritis 2 26.00 Quite Low
vagus nerve 2 19.00 Low Low
psoriasis 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 76 99.40 Very High Very High Very High
Encephalitis 4 98.78 Very High Very High Very High
Herpes Simplex Virus 2 98.32 Very High Very High Very High
Rhinitis 25 97.64 Very High Very High Very High
Viral Infection 2 96.16 Very High Very High Very High
Hypersensitivity 15 95.32 Very High Very High Very High
INFLAMMATION 63 94.96 High High
Infection 23 93.68 High High
Graft Vs Host Disease 4 91.44 High High
Carcinoma 16 90.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR3 and TLR4 expression is deregulated in peritoneal endometriosis
Regulation (deregulated) of TLR3 associated with endometriosis
1) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.10 Pain Relevance 0.05
In the current study, we report that toll-like receptor 3 and 4 expression is modulated in pathogenic alterations of the endometrium.
Regulation (modulated) of toll-like receptor 3 in endometrium
2) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.69 Pain Relevance 0.06
The herpes simplex encephalomyelitis (HSE) is caused in some cases by mutation of UNC-93B, a molecule controlling TLR3, 7, 8, 9 signalling [21](J-L Casanova, INSERM, France).
Regulation (controlling) of TLR3 associated with herpes simplex virus and encephalitis
3) Confidence 0.30 Published 2007 Journal J Transl Med Section Body Doc Link PMC2176053 Disease Relevance 0.95 Pain Relevance 0.17
An up-regulation of TLR2, TLR3 and TLR4 in the nasal mucosa of patients with symptomatic allergic rhinitis supports the idea of a role for TLRs in allergic inflammation.
Regulation (regulation) of TLR3 in nasal mucosa associated with rhinitis, inflammation and hypersensitivity
4) Confidence 0.21 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 1.24 Pain Relevance 0.21
Synthetic dsRNA, however, may also target and activate other TLR3+ or TLR3?
Spec (may) Regulation (target) of TLR3
5) Confidence 0.09 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.16 Pain Relevance 0.20

General Comments

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