INT186799

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Context Info
Confidence 0.68
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.51
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
nasal 1
neutrophils 1
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 134 100.00 Very High Very High Very High
analgesia 40 98.12 Very High Very High Very High
Pain 56 93.76 High High
Inflammation 108 93.52 High High
Enkephalin 80 90.68 High High
Endogenous opioid 4 89.52 High High
agonist 37 87.12 High High
rheumatoid arthritis 55 83.04 Quite High
IPN 38 82.36 Quite High
Hyperalgesia 10 78.12 Quite High
Disease Link Frequency Relevance Heat
Pain 58 93.76 High High
INFLAMMATION 112 93.52 High High
Osteoarthritis 34 84.84 Quite High
Rheumatoid Arthritis 56 83.04 Quite High
Rhinitis 25 83.00 Quite High
Inflammatory Pain 38 82.36 Quite High
Hyperalgesia 12 78.12 Quite High
Nociception 48 75.00 Quite High
Arthritis 12 59.36 Quite High
Hypersensitivity 12 48.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative real-time PCR (qRT-PCR, TaqMan) was performed to determine the relative TLR2, TLR4 and TLR9 mRNA expression levels using the comparative threshold cycle (??
Spec (determine) Localization (relative) of TLR2
1) Confidence 0.68 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0 Pain Relevance 0
First of all, we must acknowledge that TLR2, TLR3 and TLR4 appear to be localized mainly in the apical part of the epithelium. mRNA from nasal biopsies is comprised of a heterogeneous mix of different cells not only from the epithelium, but also from the submucosa.
Localization (localized) of TLR2 in nasal
2) Confidence 0.68 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.08 Pain Relevance 0
either cytofluorometry to detect TLR2 and TLR4 protein or RT-PCR to detect
Localization (detect) of TLR2
3) Confidence 0.41 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 0.98 Pain Relevance 0.41
This requires activation of FPR as well as intracellular Ca2+ mobilization and PI3K activation, while TLR-2 and -4 do not seem to be involved.
Localization (mobilization) of TLR-2
4) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 1.39 Pain Relevance 1.11
Stimulation of FPR but not of TLR-2 or TLR-4 elicits opioid peptide secretion from neutrophils in vitro and opioid-mediated analgesia in vivo
Localization (secretion) of TLR-2 in neutrophils associated with opioid and analgesia
5) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.06 Pain Relevance 1.06

General Comments

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