INT186800

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 1.31
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
macrophages 3
adipocytes 1
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 157 99.08 Very High Very High Very High
agonist 109 89.16 High High
cytokine 99 82.52 Quite High
Inflammatory marker 2 48.88 Quite Low
antagonist 4 33.36 Quite Low
tolerance 14 22.00 Low Low
fibrosis 36 5.00 Very Low Very Low Very Low
Inflammatory response 33 5.00 Very Low Very Low Very Low
chemokine 22 5.00 Very Low Very Low Very Low
Bile 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 185 99.08 Very High Very High Very High
Obesity 14 98.62 Very High Very High Very High
Apoptosis 29 87.68 High High
Otitis Media 1 70.08 Quite High
Chronic Disease 4 68.80 Quite High
Colon Cancer 1 61.16 Quite High
Injury 72 50.00 Quite Low
Sinusitis 4 48.48 Quite Low
Rhinitis 25 47.88 Quite Low
Neonatal Necrotizing Enterocolitis 34 43.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies using a co-culture system of adipocytes and macrophages (C3H/HeN and C3H/HeJ peritoneal macrophages, RAW264 macrophages) showed that SFA released from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis serve as a naturally occurring ligand for TLR4, thereby inducing the inflammatory changes in both adipocytes and macrophages through NF-?
Positive_regulation (occurring) of TLR4 Binding (ligand) of in macrophages associated with inflammation and obesity
1) Confidence 0.47 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.55 Pain Relevance 0.32
These results indicate that LPS could stimulate IEC secretion of IL-8, but only if TLR4 expression was first induced by treating the cells with PAF and later stimulated with TLR4 ligand.
Positive_regulation (stimulated) of TLR4 Binding (ligand) of
2) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.15 Pain Relevance 0
It might be that the increase in immunoreactivity for TLR2, TLR3 and TLR4 seen after allergen challenge only persists for a limited period of time.
Positive_regulation (increase) of TLR4 Spec (might) Binding (immunoreactivity) of
3) Confidence 0.40 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.07 Pain Relevance 0.03
Studies using a co-culture system of adipocytes and macrophages (C3H/HeN and C3H/HeJ peritoneal macrophages, RAW264 macrophages) showed that SFA released from hypertrophied adipocytes via the macrophage-induced adipocyte lipolysis serve as a naturally occurring ligand for TLR4, thereby inducing the inflammatory changes in both adipocytes and macrophages through NF-?
Positive_regulation (occurring) of TLR4 in adipocytes Binding (ligand) of in macrophages associated with inflammation and obesity
4) Confidence 0.16 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2984459 Disease Relevance 0.55 Pain Relevance 0.32

General Comments

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