INT186801

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.05
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
macrophages 2
microglia 2
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 129 99.26 Very High Very High Very High
cytokine 57 98.80 Very High Very High Very High
agonist 9 86.64 High High
Central nervous system 21 69.20 Quite High
Inflammation 24 68.00 Quite High
Osteoarthritis 15 47.28 Quite Low
imagery 27 5.00 Very Low Very Low Very Low
Pain 16 5.00 Very Low Very Low Very Low
positron emission tomography 12 5.00 Very Low Very Low Very Low
Nerve growth factor 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cold Sores 367 99.68 Very High Very High Very High
Viral Meningitis 4 99.44 Very High Very High Very High
Rheumatoid Arthritis 129 99.26 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 74 83.60 Quite High
Infection 88 75.76 Quite High
Virus Diseases 2 69.76 Quite High
Otitis Media 1 68.88 Quite High
Death 13 64.08 Quite High
Apoptosis 47 62.36 Quite High
Rhinitis 25 47.88 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It might be that the increase in immunoreactivity for TLR2, TLR3 and TLR4 seen after allergen challenge only persists for a limited period of time.
Positive_regulation (increase) of TLR2 Spec (might) Binding (immunoreactivity) of
1) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.07 Pain Relevance 0.03
These studies demonstrate that although IL-23 is not plentiful in RA SF, it is expressed in RA synovial macrophages and is greatly increased after TLR2 ligation.
Positive_regulation (increased) of TLR2 Binding (ligation) of in macrophages associated with rheumatoid arthritis
2) Confidence 0.25 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575607 Disease Relevance 1.01 Pain Relevance 0.50
TLR2 recognition may be particularly important during HSV-1 encephalitis, as microglia strongly express TLR2 [309, 310].
Positive_regulation (important) of TLR2 Binding (recognition) of in microglia associated with cold sores and viral meningitis
3) Confidence 0.21 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.89 Pain Relevance 0.13
Stimulation with TLR2 ligands
Positive_regulation (Stimulation) of TLR2 Binding (ligands) of
4) Confidence 0.16 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2970528 Disease Relevance 0.08 Pain Relevance 0

General Comments

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