INT186804

Context Info Confidence 0.45 First Reported 2005 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 14 Total Number 15 Disease Relevance 8.41 Pain Relevance 0.79

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3) intracellular (TLR3) cytoplasm (TLR3)

Anatomy Link Frequency poly 4 PDL-1 1 epithelial cells 1 TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 63 97.76 Inflammation 222 95.64 Inflammatory response 25 95.24 chemokine 67 89.00 cytokine 129 88.44 agonist 10 65.28 Central nervous system 21 47.84 fibrosis 11 45.88 adenocard 1 39.52 imagery 27 5.00

Disease Link Frequency Relevance Heat Hepatitis C Virus Infection 100 99.74 Skin Cancer 15 99.44 Carcinoma 26 98.76 Endometriosis (extended) 116 97.76 INFLAMMATION 252 95.64 Influenza Virus Infection 95 94.12 Infection 276 90.96 Adenocarcinoma 111 87.60 Viral Infection 51 86.88 Apoptosis 39 85.56

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TLR3 recognizes RNA and viruses, whereas TLR4 mediates the response to bacterial endotoxins and is activated due to sterile inflammation [33,34].

TLR3 Binding (recognizes) of associated with inflammation

1) Confidence 0.45 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.50 Pain Relevance 0.09

Concerning protein localization, we found TLR3 and TLR4 proteins in glandular and epithelial cells of endometriosis patients.

TLR3 Binding (found) of in epithelial cells associated with endometriosis

2) Confidence 0.35 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.56 Pain Relevance 0.09

In undifferentiated G3 carcinoma, staining for TLR3 (figure 6E) and TLR4 (figure 6J) was not detectable, strengthening our findings of low TLR3 and TLR4 mRNA abundance in G3 carcinoma (figure 5B).

TLR3 Binding (findings) of associated with carcinoma

3) Confidence 0.35 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.99 Pain Relevance 0

It might be that the increase in immunoreactivity for TLR2, TLR3 and TLR4 seen after allergen challenge only persists for a limited period of time.

TLR3 Spec (might) Binding (immunoreactivity) of

4) Confidence 0.29 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.07 Pain Relevance 0.03

Immunoreactivity for TLR3 was 1.39 ± 0.44 in controls (n = 9), 0.64 ± 0.25 in patients before allergen challenge (n = 11) and 2.22 ± 0.79 in patients after allergen challenge (n = 11).

TLR3 Binding (Immunoreactivity) of

5) Confidence 0.27 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0 Pain Relevance 0

TLR3, TLR8 and TLR9 are recognized by virus-derived double stranded RNA (poly-I:C), virus-derived single stranded RNA (ssRNA) and unmethylated CpG motifs, respectively.

TLR3 Binding (recognized) of in poly

6) Confidence 0.20 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 0.68 Pain Relevance 0.10

Polyriboinosinic-polyribocytoidylic acid (poly I:C), a synthetic double-stranded RNA (dsRNA), is recognized by TLR3 and other intracellular receptors.

TLR3 Binding (recognized) of in poly

7) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2660151 Disease Relevance 0.19 Pain Relevance 0

Moreover, TLR3 recognizes double-stranded (ds) RNA, assumed to be released by viral killing of cells.

TLR3 Binding (recognizes) of

8) Confidence 0.15 Published 2009 Journal Virol J Section Body Doc Link PMC2654877 Disease Relevance 1.41 Pain Relevance 0.16

The TLR3 ligation induced a MDC maturation profile with upregulation of the markers; CD40, CD83, CD86, CCR7, PDL-1, and downregulation of ICOSL, B7H3, and CCR5 (Figure 9).

TLR3 Binding (ligation) of in PDL-1

9) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955544 Disease Relevance 0.31 Pain Relevance 0

The host innate immune Toll-like receptor 3 (TLR3) was shown previously in cells of myeloid origin to recognize the viral replicative, intermediate double-stranded RNA (dsRNA).

TLR3 Binding (recognize) of

10) Confidence 0.15 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 0.49 Pain Relevance 0.05

Double-stranded HCV RNA is also recognized by TLR-3, which activates IKKe/TBK-1, via TRIF (TIR-domain-containing adapter-inducing interferon-?)

TLR-3 Binding (recognized) of associated with hepatitis c virus infection

11) Confidence 0.13 Published 2010 Journal J Transl Med Section Body Doc Link PMC2991329 Disease Relevance 0.45 Pain Relevance 0.06

Poly I:C12U, another analogue, is less toxic but also less stable in vivo than poly I:C, and TLR3 is essential for its recognition.

TLR3 Binding (recognition) of in poly

12) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2660151 Disease Relevance 0.29 Pain Relevance 0

The host innate immune Toll-like receptor 3 (TLR3) was shown previously in cells of myeloid origin to recognize the viral replicative, intermediate double-stranded RNA (dsRNA).

immune Toll-like receptor 3 Binding (recognize) of

13) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2288676 Disease Relevance 0.50 Pain Relevance 0.05

The dsRNA binding to TLR3, mimicked in vitro by incubation with polyinosine-polycytidylic acid [Poly (I:C)], leads not only to the induction of inflammatory responses but also to the development of antigen-specific adaptive immunity [40].

TLR3 Binding (binding) of in Poly associated with inflammatory response

14) Confidence 0.11 Published 2009 Journal Virol J Section Body Doc Link PMC2654877 Disease Relevance 1.49 Pain Relevance 0.17

They can be recognized by both TLR3 [18] and the melanoma differentiation-associated gene-5 (MDA-5) [19], pattern recognition receptors that are expressed by many cell types and are involved in anti-viral immune responses [20].

TLR3 Binding (recognized) of associated with skin cancer

15) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.48 Pain Relevance 0

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