INT186805

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 9.66
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR2) plasma membrane (TLR2) intracellular (TLR2)
cytoplasm (TLR2)
Anatomy Link Frequency
T cells 3
epithelial cells 1
inferior 1
blood 1
leukocytes 1
TLR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 146 99.00 Very High Very High Very High
cytokine 135 97.92 Very High Very High Very High
Inflammatory response 30 97.80 Very High Very High Very High
Inflammatory mediators 2 96.40 Very High Very High Very High
rheumatoid arthritis 145 93.52 High High
corticosteroid 8 92.72 High High
Arthritis 57 91.68 High High
spinal inflammation 94 90.84 High High
agonist 16 88.56 High High
psoriasis 19 75.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 177 99.00 Very High Very High Very High
Syndrome 22 98.88 Very High Very High Very High
Sarcoidosis 40 98.76 Very High Very High Very High
Disease 297 98.32 Very High Very High Very High
Dermatitis 28 97.96 Very High Very High Very High
Sinusitis 12 97.96 Very High Very High Very High
Rhinitis 76 97.88 Very High Very High Very High
Cancer 28 97.52 Very High Very High Very High
Skin Diseases 6 97.04 Very High Very High Very High
Lung Cancer 2 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TLR2 mRNA and surface expression has been described in human alveolar macrophages and lung epithelial cells from tumor-free lobectomy material of lung cancer patients [22].
Transcription (described) of TLR2 mRNA in epithelial cells associated with lung cancer and cancer
1) Confidence 0.63 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.75 Pain Relevance 0.07
Corresponding with the reduced surface and mRNA expression of TLR2, Pam3Cys induced lower production of TNF-?
Transcription (expression) of TLR2
2) Confidence 0.48 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2817655 Disease Relevance 0.18 Pain Relevance 0.10
In the present study, mRNA expression levels of HO-1, TLR2, and TLR4 in circulating leukocytes from BD patients were determined.
Spec (determined) Transcription (expression) of TLR2 in leukocytes associated with disease
3) Confidence 0.46 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.45 Pain Relevance 0.39
Real-time PCR demonstrated mRNA expression of TLR2, TLR3 and TLR4 in biopsies from the inferior turbinate of all tested subjects.
Transcription (expression) of TLR2 in inferior
4) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.14 Pain Relevance 0
No difference in the sinonasal mRNA expression of TLR2 and TLR4 could be demonstrated when patients with chronic sinusitis and/or nasal polyps were compared with healthy controls [3].
Transcription (expression) of TLR2 in nasal associated with rhinitis and sinusitis
5) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.74 Pain Relevance 0.12
The present study was designed to quantify mRNA and protein expressions of TLR2, TLR3 and TLR4 in the nasal mucosa of patients with seasonal allergic rhinitis, before and after pollen exposure, and to compare these findings with data derived from healthy volunteers.


Transcription (expressions) of TLR2 in pollen associated with rhinitis
6) Confidence 0.45 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.58 Pain Relevance 0.03
However, there was a reduced TLR2 mRNA expression in patients with Löfgren's syndrome, which may be of relevance for macrophage interactions with a postulated sarcoidosis pathogen, and for the characteristics of the ensuing T cell response.



Transcription (expression) of TLR2 in T cell associated with sarcoidosis and syndrome
7) Confidence 0.43 Published 2010 Journal Respir Res Section Abstract Doc Link PMC2939603 Disease Relevance 0.55 Pain Relevance 0
A representative example out of three independent RT-PCR experiments is depicted in Figure 2b: CD4+CD28null T cells express TLR2 and TLR4 mRNA, whereas TLR4 transcripts were not detected in CD4+CD28+ T cells from patients and healthy controls.
Transcription (express) of TLR2 in T cells
8) Confidence 0.43 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.48 Pain Relevance 0.31
In contrast, variable but significant levels of TLR2 mRNA were present in the CD3+CD4+CD28+ population even from healthy individuals.
Transcription (levels) of TLR2
9) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.39 Pain Relevance 0.26
To test T cells for the expression of TLR2 and TLR4 mRNA, monocyte-depleted CD4+CD28null and CD4+CD28+ T cells were isolated from patients as well as from healthy controls (CD4+CD28+ T cells).
Transcription (expression) of TLR2 in T cells
10) Confidence 0.41 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.92 Pain Relevance 0.61
It has been previously demonstrated that TLR2 and TLR4
Transcription (demonstrated) of TLR2
11) Confidence 0.40 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.22 Pain Relevance 0.73
Expression levels of HO-1, TLR2 and TLR4 mRNA were semiquantitatively analyzed using a real-time PCR technique, and HO-1 protein level was determined by immunoblotting in peripheral blood mononuclear cells (PBMCs) and polymorphonuclear leukocytes.
Spec (analyzed) Transcription (levels) of TLR2 in blood
12) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2374472 Disease Relevance 0.74 Pain Relevance 0.09
There was no abnormality in mRNA expression of TLR2 and TLR4 in PMNs (Figure 2c,d).
Transcription (expression) of TLR2
13) Confidence 0.34 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.61 Pain Relevance 0.04
mRNA expression and either induce (budesonide) or suppress (tacrolimus) TLR 2 mRNA expression in human keratinocytes [126, 127].
Transcription (expression) of TLR 2 mRNA in keratinocytes
14) Confidence 0.11 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 0.93 Pain Relevance 0.30

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