INT186808

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 22
Total Number 26
Disease Relevance 12.77
Pain Relevance 3.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
epithelial cell 3
T cells 3
endometrium 2
alveolar macrophages 1
inferior 1
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory response 155 100.00 Very High Very High Very High
Inflammatory stimuli 35 99.16 Very High Very High Very High
Inflammation 353 99.00 Very High Very High Very High
cytokine 204 98.64 Very High Very High Very High
Inflammatory mediators 5 96.40 Very High Very High Very High
rheumatoid arthritis 195 94.24 High High
Arthritis 60 91.68 High High
endometriosis 84 91.48 High High
spinal inflammation 94 90.84 High High
ischemia 8 68.56 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 523 100.00 Very High Very High Very High
Disease 687 98.72 Very High Very High Very High
Rhinitis 75 98.48 Very High Very High Very High
Sinusitis 12 98.32 Very High Very High Very High
Hypersensitivity 39 95.56 Very High Very High Very High
Herpes Simplex Virus 14 94.40 High High
Rheumatoid Arthritis 196 94.24 High High
Seronegative Spondarthritis 48 91.68 High High
Endometriosis (extended) 152 91.48 High High
Low Back Pain 94 90.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, in (1) the variable DR* is assumed to be the convoluted signal that propagates the LPS signaling initiating the transcriptional synthesis of both the pro-inflammatory response (P) and the mRNA of TLR4 (mRNA,R).
Transcription (synthesis) of TLR4 associated with inflammatory response and inflammatory stimuli
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2651450 Disease Relevance 0.78 Pain Relevance 0.44
A recent study performed on bovine endometrial cells, co-localised TLR4 transcripts with CD14 mRNA and protein to stromal and epithelial cells [35].
Transcription (transcripts) of TLR4 in epithelial cells
2) Confidence 0.68 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.19 Pain Relevance 0.07
This difference was the greatest in the shed menstrual endometrium, where TLR4 transcripts were 564-fold higher than those for TLR3.
Transcription (transcripts) of TLR4 in endometrium
3) Confidence 0.66 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.09 Pain Relevance 0.05
The TLR4 antibody was incubated as described above and was detected using Alexa Fluor 488-conjugated anti-mouse antibody (3.3 ?
Transcription (detected) of TLR4
4) Confidence 0.66 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0 Pain Relevance 0
TLR4 cell surface expression was low and comparable in alveolar macrophages and monocytes, and TLR4 mRNA lower in alveolar macrophages than monocytes.
Transcription (lower) of TLR4 in monocytes
5) Confidence 0.58 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.06 Pain Relevance 0.03
In human cornea, multiple groups have reported the expression of TLR3 [14,15], TLR4 [16,17], and TLR5 [18] mRNA and proteins.
Transcription (expression) of TLR4 in cornea
6) Confidence 0.54 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.32 Pain Relevance 0.07
On the other hand, TLR4 mRNA expression levels were elevated in PBMCs from patients, irrespective of disease activity (Figure 2b) and HLA-B51 phenotype (data not shown).
Transcription (expression) of TLR4 associated with disease
7) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.59 Pain Relevance 0
In the present study, mRNA expression levels of HO-1, TLR2, and TLR4 in circulating leukocytes from BD patients were determined.
Spec (determined) Transcription (expression) of TLR4 in leukocytes associated with disease
8) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 1.45 Pain Relevance 0.39
The results indicate that TLR4 mRNA expression is constitutively increased in PBMCs from BD patients.


Transcription (expression) of TLR4 associated with disease
9) Confidence 0.51 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.58 Pain Relevance 0.04
In agreement with Pioli et al., who detected TLR4, CD14 and MyD88 transcripts in human endometrium [14], we were able to co-localize TLR4 with CD14 proteins suggesting the presence of both interacting receptors CD14 and TLR4 in the endometrial cells.
Transcription (detected) of TLR4 in endometrium
10) Confidence 0.51 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.19 Pain Relevance 0.06
HO-1]) was significantly correlated with TLR4 mRNA expression levels in untreated PBMCs (Figure 4c).
Transcription (levels) of TLR4
11) Confidence 0.49 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.41 Pain Relevance 0.05
It has been previously demonstrated that TLR2 and TLR4
Transcription (demonstrated) of TLR4
12) Confidence 0.48 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2435281 Disease Relevance 1.28 Pain Relevance 0.75
The TLR4 gene transcript was detected in 5 out of 6 cultured limbal cell samples and 4 out of 6 cultured conjunctival epithelial cell samples.
Transcription (detected) of TLR4 in epithelial cell
13) Confidence 0.48 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
We found TLR4 transcripts in all the uncultured conjunctival epithelial cell samples.
Transcription (transcripts) of TLR4 in epithelial cell
14) Confidence 0.48 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.16 Pain Relevance 0.12
No difference in the sinonasal mRNA expression of TLR2 and TLR4 could be demonstrated when patients with chronic sinusitis and/or nasal polyps were compared with healthy controls [3].
Transcription (expression) of TLR4 in nasal associated with rhinitis and sinusitis
15) Confidence 0.42 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.74 Pain Relevance 0.12
A representative example out of three independent RT-PCR experiments is depicted in Figure 2b: CD4+CD28null T cells express TLR2 and TLR4 mRNA, whereas TLR4 transcripts were not detected in CD4+CD28+ T cells from patients and healthy controls.
Neg (not) Transcription (detected) of TLR4 in T cells
16) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.42 Pain Relevance 0.28
A representative example out of three independent RT-PCR experiments is depicted in Figure 2b: CD4+CD28null T cells express TLR2 and TLR4 mRNA, whereas TLR4 transcripts were not detected in CD4+CD28+ T cells from patients and healthy controls.
Transcription (express) of TLR4 in T cells
17) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297589 Disease Relevance 0.48 Pain Relevance 0.31
These discrepancies may be explained by differences in the time kinetics of TLR4 trafficking and surface expression and mRNA expression.
Transcription (expression) of TLR4
18) Confidence 0.39 Published 2010 Journal Respir Res Section Body Doc Link PMC2817655 Disease Relevance 0.06 Pain Relevance 0.04
There was no abnormality in mRNA expression of TLR2 and TLR4 in PMNs (Figure 2c,d).
Transcription (expression) of TLR4
19) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.61 Pain Relevance 0.04
On the other hand, TLR4 mRNA expression levels were elevated in PBMCs from patients, irrespective of disease activity (Figure 2b) and HLA-B51 phenotype (data not shown).
Transcription (levels) of TLR4 associated with disease
20) Confidence 0.38 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374472 Disease Relevance 0.59 Pain Relevance 0

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