INT186809

Context Info Confidence 0.65 First Reported 2005 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.50 Pain Relevance 0.11

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3) intracellular (TLR3) cytoplasm (TLR3)

Anatomy Link Frequency endometrium 2 TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 21 89.52 Inflammation 26 60.32 Inflammatory response 1 6.12 cytokine 10 5.00 Antihistamine 3 5.00 chemokine 2 5.00 corticosteroid 1 5.00 anesthesia 1 5.00 Dismenorea 1 5.00 pain pelvic 1 5.00

Disease Link Frequency Relevance Heat Endometriosis 12 98.94 Rhinitis 25 98.32 Endometriosis (extended) 38 89.52 INFLAMMATION 26 60.32 Hypersensitivity 10 5.00 Carcinoma 8 5.00 Adenocarcinoma 7 5.00 Asthma 6 5.00 Uterine Diseases 5 5.00 Disease 5 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Interestingly, endometriotic lesions in proliferative phase showed a significant increase of TLR3 mRNA expression (P < 0.05) when compared with the corresponding eutopic endometrium (figure 3A).

Positive_regulation (increase) of Transcription (expression) of TLR3 in endometrium associated with endometriosis

1) Confidence 0.65 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.34 Pain Relevance 0.08

The mRNA expression of TLR3 was found to be elevated among patients with on-going symptomatic allergic rhinitis.

Positive_regulation (elevated) of Transcription (expression) of TLR3 associated with rhinitis

2) Confidence 0.53 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.16 Pain Relevance 0.03

General Comments

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