INT18681

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Context Info
Confidence 0.71
First Reported 1989
Last Reported 2010
Negated 6
Speculated 3
Reported most in Body
Documents 80
Total Number 83
Disease Relevance 38.80
Pain Relevance 5.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Thy1) endoplasmic reticulum (Thy1) plasma membrane (Thy1)
enzyme binding (Thy1) cytoskeleton organization (Thy1)
Anatomy Link Frequency
stem cells 5
neuronal 4
neurons 4
fibroblast 3
DRG 3
Thy1 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 2 100.00 Very High Very High Very High
Somatostatin 5 99.86 Very High Very High Very High
Thalamus 34 99.68 Very High Very High Very High
Enkephalin 2 99.52 Very High Very High Very High
substance P 2 99.40 Very High Very High Very High
Neuropeptide 3 99.14 Very High Very High Very High
dexamethasone 11 98.78 Very High Very High Very High
Pyramidal cell 14 98.66 Very High Very High Very High
Sciatic nerve 18 98.60 Very High Very High Very High
narcan 3 98.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 1366 100.00 Very High Very High Very High
Ganglion Cysts 248 100.00 Very High Very High Very High
Retina Disease 144 100.00 Very High Very High Very High
Adhesions 32 100.00 Very High Very High Very High
Cancer 3653 99.98 Very High Very High Very High
Injury 436 99.96 Very High Very High Very High
Shock 21 99.60 Very High Very High Very High
Cold Sores 3 98.92 Very High Very High Very High
Carcinoma 274 98.68 Very High Very High Very High
Amyloid Plaque 168 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In high-grade carcinomas a subset of cells adjacent to the stroma, demarked by the strong expression of Thy1, expresses either Thy1 or Sca1 or both markers (Figure 8F).
Gene_expression (expresses) of Thy1 in stroma associated with carcinoma
1) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.62 Pain Relevance 0
To analyze Thy1 expression in WAP-T and G-2 tumors the samples were immunostained with a Thy1-specific antibody.
Spec (analyze) Gene_expression (expression) of Thy1 associated with cancer
2) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.47 Pain Relevance 0
The latter state is represented by expression of Thy1, is reversible and can most likely transit directly into a quasi-epithelial state.
Gene_expression (expression) of Thy1
3) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.45 Pain Relevance 0
In adherently growing cells, membrane-associated expression of Thy1 coincides with that of Sca1 (Figure S4B, left), whereas Epcam-positive cells are negative for Thy1 (Figure S4B, right).
Gene_expression (expression) of Thy1
4) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.08 Pain Relevance 0
In high-grade carcinomas a subset of cells adjacent to the stroma, demarked by the strong expression of Thy1, expresses either Thy1 or Sca1 or both markers (Figure 8F).
Gene_expression (expression) of Thy1 in stroma associated with carcinoma
5) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.62 Pain Relevance 0
In the G-2 cell culture, Thy1 expression characterizes a subset of cells mostly located within the CD24alow/Sca1high compartment.
Gene_expression (expression) of Thy1
6) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.45 Pain Relevance 0
In the G-2 culture, the cells distinguished by Thy1 expression represent an always variably sized population accounting for less than 15% (Figure S4A).
Gene_expression (expression) of Thy1
7) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.10 Pain Relevance 0
In low-grade WAP-T tumors we noted that Thy1 as well as Sca1 expression is mostly restricted to the stromal compartment and to adjacent tumor cells (Figure 8E).
Gene_expression (expression) of Thy1 associated with cancer
8) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.58 Pain Relevance 0
In contrast to the report by Cho et al. [33], we observed that Thy1high cells are mainly contained within the CD24alow/Sca1high subset (Figure 8A); however a small fraction of cells co-expressed Thy1 and CD24a (Figure 8B).
Gene_expression (co-expressed) of Thy1
9) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.08 Pain Relevance 0
Next, G-2 cells were separated according to Thy1 expression and after 5 days in culture re-analyzed by FACS.
Gene_expression (expression) of Thy1
10) Confidence 0.71 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.55 Pain Relevance 0
Cellular subsets sorted according to expression of CD24a, CD49f, CD61, Epcam, Sca1, and Thy1 cell surface proteins, or metabolic markers (e.g.
Gene_expression (expression) of Thy1
11) Confidence 0.71 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2920333 Disease Relevance 0.64 Pain Relevance 0
Id2 and Lpin1 are our candidate upstream modulators as they strongly correlated with the segregation of DBA/2J and C57BL/6 alleles, and their dosage levels correlated with the enhanced expression of survival genes (Thy1 and crystallin genes).
Gene_expression (expression) of Thy1
12) Confidence 0.69 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.81 Pain Relevance 0.06
Rp1, another photoreceptor-specific transcript expresses about 200-fold higher levels, while Thy1 expresses about 15 times the number of Clrn1 transcripts.
Gene_expression (expresses) of Thy1 in photoreceptor
13) Confidence 0.66 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.06 Pain Relevance 0
In parallel, to test whether VT680 activates cells in vivo, we measured levels of CD25 and CD44 expression on Thy1.2 (VT680+) and Thy1.1 (unstained) cells (Fig. 1J).
Gene_expression (expression) of Thy1
14) Confidence 0.66 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2034600 Disease Relevance 0.18 Pain Relevance 0.04
After blocking Fc receptors, using 24.G2 (from our hybridoma collection), cells were stained with the following antibodies (BD PharMingen); PE conjugated anti-B7.1 (clone 16-10A1), FITC conjugated anti-B7.2 (GL1), cytochrome conjugated anti-B220 (RA3-6B2), APC conjugated anti-Thy1.2 (53-2.1), PE conjugated anti-CD4 (H129.19), cytochrome conjugated anti-CD8 (53-6.7).
Gene_expression (conjugated) of anti-Thy1.2 in GL1
15) Confidence 0.65 Published 2005 Journal Respir Res Section Body Doc Link PMC555575 Disease Relevance 0.11 Pain Relevance 0.03
Furthermore, we found that the intensity of AAV-driven GFP expression was similar between pyramidal neurons in Emx-cre mice and basket interneurons in Pv-cre mice (GFPAAV:Emx/GFPThy1?
Gene_expression (/) of Thy1 in interneurons associated with pyramidal cell
16) Confidence 0.65 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2289876 Disease Relevance 0.07 Pain Relevance 0.27
In conclusion, the present study reports the extensive expression of CFP in most ganglion cells and their processes in the thy1-CFP transgenic mouse line [5].
Gene_expression (expression) of thy1 in ganglion cells associated with targeted disruption and ganglion cysts
17) Confidence 0.63 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2519030 Disease Relevance 0.78 Pain Relevance 0.04
The few Thy1high cells expressing Krt18 may represent either contaminating cells, or cells which are in process of transition towards the Thy1low-state (see below).
Gene_expression (expressing) of Thy1high
18) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2920333 Disease Relevance 0.18 Pain Relevance 0
Glomerular volume and expression of PCNA, Thy1, and ED1/CD68 were analyzed in kidney sections.
Spec (analyzed) Gene_expression (expression) of Thy1 in kidney
19) Confidence 0.60 Published 2008 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 18385270 Disease Relevance 0.48 Pain Relevance 0.60
Higher levels of Id2 and Lpin1 correlated with higher levels of neuronal marker Thy1 and heat-shock-like crystallin genes (Cryab, Cryba4, and Crygd).
Gene_expression (levels) of Thy1 in neuronal associated with shock
20) Confidence 0.60 Published 2007 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2759132 Disease Relevance 0.71 Pain Relevance 0.10

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