INT186810
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Young et al. reported an increase in interleukin-8 (IL-8) production after stimulating TLR3 and TLR4 in endometrial cell lines with appropriate ligands [12]. | |||||||||||||||
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Critically ill patients exhibited increase in TLR-3, 4, 7 and decrease in TLR-2 expressions. | |||||||||||||||
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A significant increase of mRNA for TLR3 was obtained during pollen season. | |||||||||||||||
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An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season.
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Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus. | |||||||||||||||
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This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level. | |||||||||||||||
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The HSV TLR-dependent response entails TLR2, TLR3, TLR2/TLR6 heterodimer, TLR8 and TLR9. | |||||||||||||||
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To determine the copy number of PCR fragments, serially diluted, gene specific standard cDNAs generated from amplicons of TLR3, TLR4 and ? | |||||||||||||||
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Synthetic dsRNA, however, may also target and activate other TLR3+ or TLR3? | |||||||||||||||
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The poly I:C analogue poly I:C12U requires TLR3 to be active in vivo [54],[55] and shows little toxicity in humans [48]. | |||||||||||||||
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Synthetic dsRNA, however, may also target and activate other TLR3+ or TLR3? | |||||||||||||||
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Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus. | |||||||||||||||
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Despite this limitation, and a report that its efficacy might be mediated via TLR-3 activation [14], 330 patients were enrolled in a phase III trial to study the safety and efficacy of bevasiranib in wet AMD [73]. | |||||||||||||||
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AGN211745 too was shown to be possibly mediating its effects in preclinical models of AMD via TLR-3 activation [14]. | |||||||||||||||
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General Comments
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