INT186810

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 6.37
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
Anatomy Link Frequency
pollen 2
poly 1
conjunctiva 1
cornea 1
TLR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 148 99.36 Very High Very High Very High
agonist 13 91.84 High High
endometriosis 42 90.64 High High
Central nervous system 23 87.64 High High
chemokine 82 86.92 High High
Inflammation 94 86.48 High High
Dismenorea 2 83.04 Quite High
pain pelvic 2 82.44 Quite High
Inflammatory response 32 64.96 Quite High
Pain 18 44.88 Quite Low
Disease Link Frequency Relevance Heat
Age-related Macular Degeneration 14 99.90 Very High Very High Very High
Critical Illness 74 99.60 Very High Very High Very High
Cold Sores 367 99.52 Very High Very High Very High
Toxicity 29 98.56 Very High Very High Very High
Disease 80 96.32 Very High Very High Very High
Rhinitis 50 95.40 Very High Very High Very High
Infection 131 94.20 High High
Influenza Virus Infection 33 90.76 High High
Endometriosis (extended) 76 90.64 High High
Virus Diseases 2 88.20 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Young et al. reported an increase in interleukin-8 (IL-8) production after stimulating TLR3 and TLR4 in endometrial cell lines with appropriate ligands [12].
Positive_regulation (stimulating) of TLR3
1) Confidence 0.65 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.04 Pain Relevance 0.49
Critically ill patients exhibited increase in TLR-3, 4, 7 and decrease in TLR-2 expressions.
Positive_regulation (increase) of TLR-3 associated with critical illness
2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.64 Pain Relevance 0.07
A significant increase of mRNA for TLR3 was obtained during pollen season.
Positive_regulation (increase) of TLR3 in pollen
3) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.42 Pain Relevance 0.07
An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season.


Positive_regulation (increase) of Toll-like receptor 3 in pollen
4) Confidence 0.36 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1243240 Disease Relevance 0.35 Pain Relevance 0
Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus.
Positive_regulation (results) of TLR3 in cornea
5) Confidence 0.33 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.
Positive_regulation (elevated) of TLR3 associated with cytokine
6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.12 Pain Relevance 0.18
The HSV TLR-dependent response entails TLR2, TLR3, TLR2/TLR6 heterodimer, TLR8 and TLR9.
Positive_regulation (entails) of TLR3 associated with cold sores
7) Confidence 0.21 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.39 Pain Relevance 0.16
To determine the copy number of PCR fragments, serially diluted, gene specific standard cDNAs generated from amplicons of TLR3, TLR4 and ?
Positive_regulation (generated) of TLR3
8) Confidence 0.21 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0 Pain Relevance 0
Synthetic dsRNA, however, may also target and activate other TLR3+ or TLR3?
Positive_regulation (activate) of TLR3
9) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.16 Pain Relevance 0.20
The poly I:C analogue poly I:C12U requires TLR3 to be active in vivo [54],[55] and shows little toxicity in humans [48].
Positive_regulation (active) of TLR3 in poly associated with toxicity
10) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.30 Pain Relevance 0
Synthetic dsRNA, however, may also target and activate other TLR3+ or TLR3?
Positive_regulation (activate) of TLR3
11) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.16 Pain Relevance 0.20
Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus.
Positive_regulation (results) of TLR3 in conjunctiva
12) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0
Despite this limitation, and a report that its efficacy might be mediated via TLR-3 activation [14], 330 patients were enrolled in a phase III trial to study the safety and efficacy of bevasiranib in wet AMD [73].
Positive_regulation (activation) of TLR-3 associated with age-related macular degeneration
13) Confidence 0.07 Published 2010 Journal Silence Section Body Doc Link PMC2908561 Disease Relevance 0.38 Pain Relevance 0
AGN211745 too was shown to be possibly mediating its effects in preclinical models of AMD via TLR-3 activation [14].
Positive_regulation (activation) of TLR-3 associated with age-related macular degeneration
14) Confidence 0.06 Published 2010 Journal Silence Section Body Doc Link PMC2908561 Disease Relevance 0.41 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox