INT186810

Context Info Confidence 0.65 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 13 Total Number 14 Disease Relevance 6.37 Pain Relevance 1.37

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3) intracellular (TLR3) cytoplasm (TLR3)

Anatomy Link Frequency pollen 2 poly 1 conjunctiva 1 cornea 1 TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 148 99.36 agonist 13 91.84 endometriosis 42 90.64 Central nervous system 23 87.64 chemokine 82 86.92 Inflammation 94 86.48 Dismenorea 2 83.04 pain pelvic 2 82.44 Inflammatory response 32 64.96 Pain 18 44.88

Disease Link Frequency Relevance Heat Age-related Macular Degeneration 14 99.90 Critical Illness 74 99.60 Cold Sores 367 99.52 Toxicity 29 98.56 Disease 80 96.32 Rhinitis 50 95.40 Infection 131 94.20 Influenza Virus Infection 33 90.76 Endometriosis (extended) 76 90.64 Virus Diseases 2 88.20

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Young et al. reported an increase in interleukin-8 (IL-8) production after stimulating TLR3 and TLR4 in endometrial cell lines with appropriate ligands [12].

Positive_regulation (stimulating) of TLR3

1) Confidence 0.65 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.04 Pain Relevance 0.49

Critically ill patients exhibited increase in TLR-3, 4, 7 and decrease in TLR-2 expressions.

Positive_regulation (increase) of TLR-3 associated with critical illness

2) Confidence 0.37 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2948498 Disease Relevance 0.64 Pain Relevance 0.07

A significant increase of mRNA for TLR3 was obtained during pollen season.

Positive_regulation (increase) of TLR3 in pollen

3) Confidence 0.36 Published 2005 Journal Respir Res Section Body Doc Link PMC1243240 Disease Relevance 0.42 Pain Relevance 0.07

An increase in protein expression for all three receptors could be seen following allergen challenge, whereas a significant increase of mRNA only could be obtained for Toll-like receptor 3 during pollen season.

Positive_regulation (increase) of Toll-like receptor 3 in pollen

4) Confidence 0.36 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1243240 Disease Relevance 0.35 Pain Relevance 0

Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus.

Positive_regulation (results) of TLR3 in cornea

5) Confidence 0.33 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0

This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.

Positive_regulation (elevated) of TLR3 associated with cytokine

6) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.12 Pain Relevance 0.18

The HSV TLR-dependent response entails TLR2, TLR3, TLR2/TLR6 heterodimer, TLR8 and TLR9.

Positive_regulation (entails) of TLR3 associated with cold sores

7) Confidence 0.21 Published 2010 Journal The Open Virology Journal Section Body Doc Link PMC2936037 Disease Relevance 1.39 Pain Relevance 0.16

To determine the copy number of PCR fragments, serially diluted, gene specific standard cDNAs generated from amplicons of TLR3, TLR4 and ?

Positive_regulation (generated) of TLR3

8) Confidence 0.21 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0 Pain Relevance 0

Synthetic dsRNA, however, may also target and activate other TLR3+ or TLR3?

Positive_regulation (activate) of TLR3

9) Confidence 0.17 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.16 Pain Relevance 0.20

The poly I:C analogue poly I:C12U requires TLR3 to be active in vivo [54],[55] and shows little toxicity in humans [48].

Positive_regulation (active) of TLR3 in poly associated with toxicity

10) Confidence 0.16 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.30 Pain Relevance 0

Synthetic dsRNA, however, may also target and activate other TLR3+ or TLR3?

Positive_regulation (activate) of TLR3

11) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2660151 Disease Relevance 0.16 Pain Relevance 0.20

Some positive results for TLR2, TLR3, and TLR5 were also seen in stromal fibroblasts of the conjunctiva, cornea, and limbus.

Positive_regulation (results) of TLR3 in conjunctiva

12) Confidence 0.11 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0 Pain Relevance 0

Despite this limitation, and a report that its efficacy might be mediated via TLR-3 activation [14], 330 patients were enrolled in a phase III trial to study the safety and efficacy of bevasiranib in wet AMD [73].

Positive_regulation (activation) of TLR-3 associated with age-related macular degeneration

13) Confidence 0.07 Published 2010 Journal Silence Section Body Doc Link PMC2908561 Disease Relevance 0.38 Pain Relevance 0

AGN211745 too was shown to be possibly mediating its effects in preclinical models of AMD via TLR-3 activation [14].

Positive_regulation (activation) of TLR-3 associated with age-related macular degeneration

14) Confidence 0.06 Published 2010 Journal Silence Section Body Doc Link PMC2908561 Disease Relevance 0.41 Pain Relevance 0

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