INT186848

Context Info Confidence 0.07 First Reported 2005 Last Reported 2005 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.11

plasma membrane (HLA-F)

Anatomy Link Frequency immune system 2 HLA-F (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 13 99.64 iatrogenic 4 5.00 chemokine 4 5.00 Inflammation 3 5.00 withdrawal 2 5.00 corticosteroid 1 5.00 Central nervous system 1 5.00 Multiple sclerosis 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Viremia 2 86.60 Infection 168 81.84 Disease 56 81.12 Hypergammaglobulinemia 1 74.48 Sarcoma 195 72.96 Acquired Immune Deficiency Syndrome Or Hiv Infection 113 50.52 Viral Infection 7 28.48 Contagious Ecthyma 61 5.00 Epstein-barr Virus 47 5.00 Lymphatic System Cancer 37 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These pathogenic effects can promote active changes in the infected human host, such as to increase cytokine production or to suppress MHC Class I (MHC I) presentation of viral proteins to the immune system.

Negative_regulation (suppress) of Gene_expression (presentation) of MHC Class I in immune system associated with cytokine

1) Confidence 0.07 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.59 Pain Relevance 0.11

General Comments

This test has worked.