INT186850

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 2.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (EBNA1BP2) nucleus (EBNA1BP2) ribosome biogenesis (EBNA1BP2)
EBNA1BP2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 5.00 Very Low Very Low Very Low
Inflammation 10 5.00 Very Low Very Low Very Low
Lasting pain 7 5.00 Very Low Very Low Very Low
fibrosis 7 5.00 Very Low Very Low Very Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
iatrogenic 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 173 99.40 Very High Very High Very High
Nasopharynx Cancer 147 99.12 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 120 97.76 Very High Very High Very High
Convalescence 2 93.48 High High
Epstein-barr Virus 133 91.88 High High
Cancer 76 56.08 Quite High
Herpes Simplex Virus 30 50.16 Quite High
Malignant Neoplastic Disease 8 25.44 Quite Low
Herpes Virus Infection 3 15.68 Low Low
Sarcoma 195 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is thought that EBNA-1 interacts with chromosomes in two different ways.
EBNA-1 Binding (interacts) of
1) Confidence 0.39 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.15 Pain Relevance 0
During metaphase/anaphase, there is additional binding of EBNA-1 to a cellular protein referred to as EBP2 (EBNA1-binding protein 2), which strengthens the association of EBNA-1 with mitotic chromosomes [75].

3.2.

EBNA-1 Binding (binding) of
2) Confidence 0.39 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.08 Pain Relevance 0
During interphase (and probably also in mitosis), EBNA-1 associates with chromatin through its binding to either cellular DNA or chromatin-associated proteins.
EBNA-1 Binding (associates) of
3) Confidence 0.39 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.09 Pain Relevance 0
During interphase (and probably also in mitosis), EBNA-1 associates with chromatin through its binding to either cellular DNA or chromatin-associated proteins.
EBNA-1 Binding (binding) of
4) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.09 Pain Relevance 0
As mentioned above, the binding of EBNA-1 to the DS element of OriP destabilizes nucleosomes and aids the recruitment of cellular replication factors to OriP.
EBNA-1 Binding (binding) of associated with acquired immune deficiency syndrome or hiv infection
5) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.16 Pain Relevance 0
During metaphase/anaphase, there is additional binding of EBNA-1 to a cellular protein referred to as EBP2 (EBNA1-binding protein 2), which strengthens the association of EBNA-1 with mitotic chromosomes [75].

3.2.

EBNA-1 Binding (association) of
6) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.08 Pain Relevance 0
The EBNA-1 protein can bind to both the FR and DS sequences [69], whereby the DS element is the initiation site of episomal DNA replication whereas FR acts as a replication fork barrier and termination site [70].
EBNA-1 protein Binding (bind) of
7) Confidence 0.29 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2938438 Disease Relevance 0.22 Pain Relevance 0
The EBP2 was completed by 933 subjects of which 898 were students from a potential 1676 students enrolled in the included bachelor programs (student response rate 54%).
EBP2 Binding (completed) of
8) Confidence 0.29 Published 2010 Journal BMC Med Educ Section Body Doc Link PMC2966458 Disease Relevance 0 Pain Relevance 0
The results of immunoprecipitation suggested a direct interaction between EBNA-5 and p63 protein in NPC, and this binding would increase the stability of p63.
EBNA Binding (interaction) of associated with nasopharynx cancer
9) Confidence 0.10 Published 2007 Journal Mol Cancer Section Body Doc Link PMC1774581 Disease Relevance 1.25 Pain Relevance 0
This delayed EBNA1 response is probably not due to the delay in immune recognition of the latently infected cells or of the released latent antigen because EBNA2 is recognized shortly after infection.
EBNA2 Binding (recognized) of associated with infection
10) Confidence 0.04 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.79 Pain Relevance 0

General Comments

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