INT186862

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Context Info
Confidence 0.60
First Reported 2004
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 6.15
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Pon1) extracellular region (Pon1) lipid metabolic process (Pon1)
Anatomy Link Frequency
liver 3
Costa 1
Pon1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 64 87.68 High High
cytokine 4 80.08 Quite High
peripheral neuropathy 2 78.08 Quite High
anesthesia 20 75.52 Quite High
Inflammatory response 4 66.96 Quite High
chemokine 4 37.68 Quite Low
Neurobehavioral 18 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disorder Of Lipid Metabolism 300 100.00 Very High Very High Very High
Stress 124 100.00 Very High Very High Very High
Pneumoperitoneum 44 100.00 Very High Very High Very High
Liver Disease 60 98.80 Very High Very High Very High
Toxicity 1 98.52 Very High Very High Very High
Disease 42 97.88 Very High Very High Very High
Gallstones 12 93.44 High High
Hepatotoxicity 8 93.36 High High
Drug Induced Neurotoxicity 21 89.72 High High
Genetic Predisposition To Disease 4 88.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A likely possibility (and one which does not exclude an inhibition by lipid peroxidation products) is that, in advanced liver impairment, changes in HDL structure and composition influence PON1 activity.
Regulation (changes) of PON1 in liver associated with disorder of lipid metabolism
1) Confidence 0.60 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 0.67 Pain Relevance 0
A likely hypothesis is that PON1 activity is influenced by alterations in HDL structure and composition, secondary to an impaired synthesis of this lipoprotein by the liver.
Regulation (influenced) of PON1 in liver associated with disorder of lipid metabolism
2) Confidence 0.60 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.12 Pain Relevance 0.11
In addition, no significant changes in TOS, TAS, PON1, and arylesterase activities were noticed in Group II.
Neg (no) Regulation (changes) of PON1
3) Confidence 0.50 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.25 Pain Relevance 0
In contrast, no significant changes in TOS, TAS, PON1, and arylesterase activities were observed in Group II.
Neg (no) Regulation (changes) of PON1
4) Confidence 0.50 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.63 Pain Relevance 0
Mean and SD values of PON1 and arylesterase activities, as well as TAS and TOS levels are presented in Table 2.
Regulation (values) of PON1
5) Confidence 0.50 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2845769 Disease Relevance 0.16 Pain Relevance 0.05
Alterations in circulating PON1 levels have been found associated with a variety of diseases involving oxidative stress [5,6].
Regulation (Alterations) of PON1 associated with stress and disease
6) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.20 Pain Relevance 0.20
The molecular bases underlying the alterations in the circulating PON1 activity together with its synthesis and secretion in chronic liver diseases are far from being completely understood, despite these changes being of crucial importance in the pathophysiology of chronic liver impairment.
Regulation (alterations) of PON1 in liver associated with liver disease
7) Confidence 0.26 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2877049 Disease Relevance 1.11 Pain Relevance 0.03
Herein, we investigated the effects of pneumoperitoneum on oxidative stress markers, including paraoxonase, arylesterase, total oxidant status, and total antioxidant status, during laparoscopic cholecystectomy.


Spec (investigated) Regulation (effects) of paraoxonase associated with stress and pneumoperitoneum
8) Confidence 0.22 Published 2010 Journal Clinics (Sao Paulo) Section Abstract Doc Link PMC2845769 Disease Relevance 0.56 Pain Relevance 0.08
Animal studies suggest that changes in serum paraoxonase activity alter susceptibility to OP toxicity (Costa et al. 2003).
Regulation (changes) of serum paraoxonase in Costa associated with toxicity
9) Confidence 0.01 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247187 Disease Relevance 0.44 Pain Relevance 0.04

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