INT186872

Context Info Confidence 0.24 First Reported 2004 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 6 Total Number 43 Disease Relevance 1.33 Pain Relevance 2.07

extracellular region (C4bpa) cytoplasm (C4bpa)

Anatomy Link Frequency placenta 12 liver 3 uterine 3 urine 2 blood vessels 1 C4bpa (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 380 99.40 anesthesia 82 89.68 Central nervous system 20 78.24 monoamine 62 73.84 agonist 6 71.36 ketamine 6 70.92 antagonist 11 67.00 Hippocampus 24 62.00 Opioid 38 39.52 Pyramidal cell 21 28.08

Disease Link Frequency Relevance Heat Aging 9 91.76 Toxicity 96 88.28 Congenital Anomalies 42 79.20 Stress Incontinence 38 75.92 Cognitive Disorder 13 72.04 Shock 30 62.96 Anxiety Disorder 24 61.28 Body Weight 21 43.44 Exsanguination 2 10.40 Death 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Worldwide production of BPA has increased and will most likely continue to increase in the future (Staples et al. 1998).

Gene_expression (production) of BPA

1) Confidence 0.24 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0.20 Pain Relevance 0.14

The dams were orally exposed to BPA (0.1 mg/kg/day; Tokyo Kasei Kogyo, Tokyo, Japan) or NP (0.1 or 10 mg/kg/day; Tokyo Kasei Kogyo) dissolved in corn oil, or to corn oil alone (vehicle control; 2 mL/kg/day) from GD3 until postnatal day (PND)20.

Gene_expression (exposed) of BPA

2) Confidence 0.24 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0.07 Pain Relevance 0.07

Although it remains to be determined whether such effects have a significant impact on the health of human and animal populations exposed to BPA, the current exposure limits clearly do not provide a wide margin of safety in terms of the acute estrogen-dependent regulation of CA1 PSSD.

Gene_expression (exposed) of BPA in margin

3) Confidence 0.19 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0.16 Pain Relevance 0.06

g/kg) plus BPA (300 ?

Gene_expression (plus) of BPA

4) Confidence 0.19 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.26

The same dose of BPA also inhibited the increase in PSSD induced by 17?

Gene_expression (dose) of BPA

5) Confidence 0.19 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.07

In the present study, we hypothesized that BPA-GA is transferred across the placenta to the fetus and then adversely affects the fetus by reactivation to BPA.

Gene_expression (transferred) of BPA in placenta

6) Confidence 0.06 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.13

These results suggest that placental transfer of BPA-GA occurs in a selective manner.

Gene_expression (transfer) of BPA

7) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04

The uterine perfusion experiment showed that only BPA-GA was transferred across the placenta into the fetus.

Gene_expression (transferred) of BPA in placenta

8) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

Thus, the kinetic study detected BPA-GA and BPA in fetal tissues, although in small amounts.

Gene_expression (detected) of BPA

9) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

Thus, we examined the expression and localization of the placental transporters that would possibly mediate the transfer of BPA-GA.

Gene_expression (transfer) of BPA

10) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

Thus, the kinetic study detected BPA-GA and BPA in fetal tissues, although in small amounts.

Gene_expression (detected) of BPA

11) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

First, BPA-GA is transferred into the fetus through the placenta, even if only in small amounts.

Gene_expression (transferred) of BPA in placenta

12) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.06 Pain Relevance 0

These localization patterns suggest that BPA-GA is transferred into trophoblast cells from maternal blood vessels by Oatp4a1 and is then excreted into fetal blood from the trophoblasts by Mrp1.

Gene_expression (transferred) of BPA in blood vessels

13) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

These results demonstrate that BPA-GA is transferred into the fetus and deconjugated in the fetus because of its vulnerable drug-metabolizing system.

Gene_expression (transferred) of BPA

14) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

Nevertheless, we detected not only BPA-GA but also deconjugated BPA in the fetus and amniotic fluid after uterine perfusion.

Gene_expression (detected) of BPA in uterine

15) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05

To test this hypothesis, we examined whether BPA-GA is passed through the placenta and whether it is reactivated in the fetus.

Gene_expression (passed) of BPA in placenta

16) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.14

As shown in Table 1, BPA-GA was also detected in the fetus.

Gene_expression (detected) of BPA

17) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

BPA exposure during the fetal and lactational periods affects sexual differentiation of the brain structure and behavior at a dosage less than the human tolerable daily intake level (50 ?

Gene_expression (exposure) of BPA in brain structure

18) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0.23 Pain Relevance 0.09

Previously, we found that BPA is highly glucuronidated by UGT2B1, an isoform of uridine 5?

Gene_expression (glucuronidated) of BPA

19) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.07

The detection of BPA indicates the possibility that BPA-GA is deconjugated by fetal ?

Gene_expression (detection) of BPA

20) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.05

General Comments

This test has worked.