INT186873

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Context Info
Confidence 0.18
First Reported 2004
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 11
Disease Relevance 0.39
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (C4bpa) cytoplasm (C4bpa)
Anatomy Link Frequency
placenta 10
C4bpa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 80 86.36 High High
Central nervous system 20 78.24 Quite High
agonist 2 71.36 Quite High
antagonist 5 67.00 Quite High
monoamine 62 64.04 Quite High
anesthesia 18 13.52 Low Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Opioid 8 5.00 Very Low Very Low Very Low
Pyramidal cell 7 5.00 Very Low Very Low Very Low
Neurobehavioral 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 7 72.04 Quite High
Shock 30 62.96 Quite High
Anxiety Disorder 24 61.28 Quite High
Stress Incontinence 8 49.04 Quite Low
Congenital Anomalies 12 47.92 Quite Low
Body Weight 19 24.40 Low Low
Toxicity 32 18.24 Low Low
Death 4 5.00 Very Low Very Low Very Low
Aging 3 5.00 Very Low Very Low Very Low
Exsanguination 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Worldwide production of BPA has increased and will most likely continue to increase in the future (Staples et al. 1998).
Positive_regulation (increased) of Gene_expression (production) of BPA
1) Confidence 0.18 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0.20 Pain Relevance 0.14
Worldwide production of BPA has increased and will most likely continue to increase in the future (Staples et al. 1998).
Positive_regulation (increase) of Gene_expression (production) of BPA
2) Confidence 0.18 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0.20 Pain Relevance 0.14
The same dose of BPA also inhibited the increase in PSSD induced by 17?
Positive_regulation (dose) of Gene_expression (dose) of BPA
3) Confidence 0.14 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.07
In the present study, we hypothesized that BPA-GA is transferred across the placenta to the fetus and then adversely affects the fetus by reactivation to BPA.
Positive_regulation (transferred) of Gene_expression (transferred) of BPA in placenta
4) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.13
Thus, we examined the expression and localization of the placental transporters that would possibly mediate the transfer of BPA-GA.
Spec (possibly) Positive_regulation (mediate) of Gene_expression (transfer) of BPA
5) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
These results suggest that placental transfer of BPA-GA occurs in a selective manner.
Positive_regulation (transfer) of Gene_expression (transfer) of BPA
6) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04
The uterine perfusion experiment showed that only BPA-GA was transferred across the placenta into the fetus.
Positive_regulation (transferred) of Gene_expression (transferred) of BPA in placenta
7) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0
Another possibility is that BPA-GA is deconjugated in the placenta and then resultant BPA is transferred into the fetus by passive diffusion.
Positive_regulation (transferred) of Gene_expression (transferred) of BPA in placenta
8) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.03
This suggests that the concentration of BPA-GA in maternal blood is increased for the entire gestational period and that, consequently, there is an increased risk of BPA-GA transfer across the placenta.
Positive_regulation (increased) of Gene_expression (transfer) of BPA in placenta
9) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04
To test our hypothesis that BPA-GA—an inactive metabolite—is passed through the placenta to the fetus, where it affects the fetus after reactivation, we investigated the placental transfer of BPA-GA and reactivation to BPA in the fetus.


Spec (investigated) Positive_regulation (transfer) of Spec (investigated) Gene_expression (transfer) of BPA in placenta
10) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04
To our knowledge, this is the first study to demonstrate the placental transfer of BPA-GA itself and the reactivation of BPA-GA to BPA in the fetus.
Positive_regulation (transfer) of Gene_expression (transfer) of BPA
11) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

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