INT186873

Context Info Confidence 0.18 First Reported 2004 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 4 Total Number 11 Disease Relevance 0.39 Pain Relevance 0.62

extracellular region (C4bpa) cytoplasm (C4bpa)

Anatomy Link Frequency placenta 10 C4bpa (Rattus norvegicus)

Pain Link Frequency Relevance Heat Bile 80 86.36 Central nervous system 20 78.24 agonist 2 71.36 antagonist 5 67.00 monoamine 62 64.04 anesthesia 18 13.52 Hippocampus 8 5.00 Opioid 8 5.00 Pyramidal cell 7 5.00 Neurobehavioral 4 5.00

Disease Link Frequency Relevance Heat Cognitive Disorder 7 72.04 Shock 30 62.96 Anxiety Disorder 24 61.28 Stress Incontinence 8 49.04 Congenital Anomalies 12 47.92 Body Weight 19 24.40 Toxicity 32 18.24 Death 4 5.00 Aging 3 5.00 Exsanguination 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Worldwide production of BPA has increased and will most likely continue to increase in the future (Staples et al. 1998).

Positive_regulation (increased) of Gene_expression (production) of BPA

1) Confidence 0.18 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0.20 Pain Relevance 0.14

Worldwide production of BPA has increased and will most likely continue to increase in the future (Staples et al. 1998).

Positive_regulation (increase) of Gene_expression (production) of BPA

2) Confidence 0.18 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247475 Disease Relevance 0.20 Pain Relevance 0.14

The same dose of BPA also inhibited the increase in PSSD induced by 17?

Positive_regulation (dose) of Gene_expression (dose) of BPA

3) Confidence 0.14 Published 2005 Journal Environ Health Perspect Section Body Doc Link PMC1257590 Disease Relevance 0 Pain Relevance 0.07

In the present study, we hypothesized that BPA-GA is transferred across the placenta to the fetus and then adversely affects the fetus by reactivation to BPA.

Positive_regulation (transferred) of Gene_expression (transferred) of BPA in placenta

4) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.13

Thus, we examined the expression and localization of the placental transporters that would possibly mediate the transfer of BPA-GA.

Spec (possibly) Positive_regulation (mediate) of Gene_expression (transfer) of BPA

5) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

These results suggest that placental transfer of BPA-GA occurs in a selective manner.

Positive_regulation (transfer) of Gene_expression (transfer) of BPA

6) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04

The uterine perfusion experiment showed that only BPA-GA was transferred across the placenta into the fetus.

Positive_regulation (transferred) of Gene_expression (transferred) of BPA in placenta

7) Confidence 0.05 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

Another possibility is that BPA-GA is deconjugated in the placenta and then resultant BPA is transferred into the fetus by passive diffusion.

Positive_regulation (transferred) of Gene_expression (transferred) of BPA in placenta

8) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.03

This suggests that the concentration of BPA-GA in maternal blood is increased for the entire gestational period and that, consequently, there is an increased risk of BPA-GA transfer across the placenta.

Positive_regulation (increased) of Gene_expression (transfer) of BPA in placenta

9) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04

To test our hypothesis that BPA-GA—an inactive metabolite—is passed through the placenta to the fetus, where it affects the fetus after reactivation, we investigated the placental transfer of BPA-GA and reactivation to BPA in the fetus.

Spec (investigated) Positive_regulation (transfer) of Spec (investigated) Gene_expression (transfer) of BPA in placenta

10) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Abstract Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0.04

To our knowledge, this is the first study to demonstrate the placental transfer of BPA-GA itself and the reactivation of BPA-GA to BPA in the fetus.

Positive_regulation (transfer) of Gene_expression (transfer) of BPA

11) Confidence 0.03 Published 2010 Journal Environ Health Perspect Section Body Doc Link PMC2944077 Disease Relevance 0 Pain Relevance 0

General Comments

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