INT186889

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Context Info
Confidence 0.05
First Reported 2004
Last Reported 2004
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.06
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (PC) immune system process (AHR) small molecule metabolic process (PC)
cell morphogenesis (AHR) carbohydrate metabolic process (PC) DNA binding (AHR)
AHR (Homo sapiens)
PC (Homo sapiens)
Pain Link Frequency Relevance Heat
alcohol 12 5.00 Very Low Very Low Very Low
cINOD 10 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 8 100.00 Very High Very High Very High
Colon Cancer 54 90.00 High High
Breast Cancer 6 86.48 High High
Cancer 66 61.64 Quite High
Pancreatic Cancer 4 55.68 Quite High
Hodgkin's Disease 2 51.56 Quite High
Obesity 34 36.52 Quite Low
Disease 16 5.00 Very Low Very Low Very Low
Weight Loss 8 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although PCB-118 has a toxic equivalency factor (TEF) of 0.0001, based on its toxicity relative to 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (Van den Berg et al. 1998), PCB-28 has not been assigned a TEF under this scheme and may not, therefore, bind strongly to the Ah receptor and/or significantly induce CYP enzymes.
Ah receptor Neg (not) Binding (bind) of PCB-28 associated with toxicity
1) Confidence 0.05 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.46 Pain Relevance 0
Although PCB-118 has a toxic equivalency factor (TEF) of 0.0001, based on its toxicity relative to 2,3,7,8-tetrachlorinated dibenzo-p-dioxin (Van den Berg et al. 1998), PCB-28 has not been assigned a TEF under this scheme and may not, therefore, bind strongly to the Ah receptor and/or significantly induce CYP enzymes.
Ah receptor Neg (not) Binding (bind) of PCB-118 associated with toxicity
2) Confidence 0.04 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.59 Pain Relevance 0

General Comments

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