INT186893

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 13
Disease Relevance 6.19
Pain Relevance 2.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (BGLAP) extracellular region (BGLAP) cell adhesion (BGLAP)
Golgi apparatus (BGLAP) structural molecule activity (BGLAP) cytoplasm (BGLAP)
Anatomy Link Frequency
plasma 1
liver 1
gut 1
microglial cells 1
BGLAP (Homo sapiens)
Pain Link Frequency Relevance Heat
5HT 141 100.00 Very High Very High Very High
Central nervous system 4 100.00 Very High Very High Very High
Arthritis 268 99.60 Very High Very High Very High
endometriosis 55 96.32 Very High Very High Very High
Inflammation 61 93.20 High High
cytokine 36 92.16 High High
chemokine 6 91.04 High High
headache 3 88.48 High High
Paracetamol 3 83.28 Quite High
Osteoarthritis 57 77.40 Quite High
Disease Link Frequency Relevance Heat
Ovarian Cancer 130 100.00 Very High Very High Very High
Seronegative Spondarthritis 234 99.60 Very High Very High Very High
Influenza In Birds 9 99.60 Very High Very High Very High
Obesity 35 98.20 Very High Very High Very High
Gynecological Disease 1 97.16 Very High Very High Very High
Wound Healing 3 96.48 Very High Very High Very High
Endometriosis 56 96.32 Very High Very High Very High
Toxicity 35 94.12 High High
INFLAMMATION 42 93.20 High High
Influenza Virus Infection 72 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since endometriosis is a common benign gynecological disorder affecting 10% of women during their reproductive years [19], with a reported prevalence going as high as 15-25% in some studies [18,20], any association with OC is concerning.
OC Binding (association) of associated with endometriosis, ovarian cancer and gynecological disease
1) Confidence 0.37 Published 2010 Journal J Ovarian Res Section Body Doc Link PMC2822768 Disease Relevance 1.22 Pain Relevance 0.20
At baseline, serum osteocalcin and urinary deoxypyridinoline crosslinks and creatinine were determined as markers of bone formation and resorption, respectively[21].
osteocalcin Binding (crosslinks) of
2) Confidence 0.35 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1693558 Disease Relevance 0.36 Pain Relevance 0
With this in mind, the potential for clinically relevant interactions between oseltamivir and OC and a variety of commonly used medications has been widely studied.
OC Binding (interactions) of
3) Confidence 0.28 Published 2010 Journal Journal of Antimicrobial Chemotherapy Section Body Doc Link PMC2835511 Disease Relevance 0.15 Pain Relevance 0.24
Although the overall model (including age, sex, and BMI) predicting BMLs was statistically significant for each biomarker, neither Ln-BSAP or Ln-osteocalcin exhibited a statistically significant univariate association with BMLs, regardless of how BMLs were defined.
osteocalcin Binding (exhibited) of associated with obesity
4) Confidence 0.27 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575616 Disease Relevance 0.23 Pain Relevance 0.10
The pregnant patient had plasma OC concentrations over the 12 hours, exceeding ?
OC Binding (concentrations) of in plasma
5) Confidence 0.22 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2565445 Disease Relevance 0.39 Pain Relevance 0.09
OC could enter the gut of wildfowl from ingested river water and interact with the avian influenza neuraminidase.
OC Binding (interact) of in gut associated with influenza in birds
6) Confidence 0.21 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592279 Disease Relevance 0.29 Pain Relevance 0
OC binds tightly to the highly conserved active site of the viral NA (Air and Laver 1989; Baker et al. 1987), thereby inhibiting the action of the enzyme that is needed for release of progeny virions from the surface of infected cells (Bardsley-Elliot and Noble 1999; Palese and Compans 1976).
OC Binding (binds) of
7) Confidence 0.13 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC1797841 Disease Relevance 0.52 Pain Relevance 0
We were puzzled by our contradictory data in PsA subjects where the majority of OC were derived from CD16+ cells.
OC Binding (majority) of associated with arthritis
8) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 1.04 Pain Relevance 0.76
They are thought to arise from circulating monocytes, which migrate to tissues and develop specific phenotypes such as Kupffer cells in the liver, microglial cells in the central nervous system and OC in bone [27,23].
OC Binding (migrate) of in liver associated with central nervous system
9) Confidence 0.10 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.29 Pain Relevance 0.14
Therefore, these reports fail to establish any clear association between 5HT turnover characteristics and OC symptoms.
OC Neg (fail) Spec (clear) Binding (association) of associated with 5ht
10) Confidence 0.07 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2416754 Disease Relevance 0.59 Pain Relevance 0.34
OC levels and interaction with other variables.
OC Binding (interaction) of
11) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247607 Disease Relevance 0.39 Pain Relevance 0
They are thought to arise from circulating monocytes, which migrate to tissues and develop specific phenotypes such as Kupffer cells in the liver, microglial cells in the central nervous system and OC in bone [27,23].
OC Binding (migrate) of in microglial cells associated with central nervous system
12) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2875642 Disease Relevance 0.29 Pain Relevance 0.14
This review will provide a brief overview of the development and relevant clinical pharmacology of PLD, but will primarily focus on its clinical use in OC and the adverse events associated with this use.


OC Binding (use) of associated with ovarian cancer
13) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2731020 Disease Relevance 0.46 Pain Relevance 0

General Comments

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