INT1869

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Context Info
Confidence 0.42
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 5.51
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SLC17A5) plasma membrane (SLC17A5) transmembrane transport (SLC17A5)
Anatomy Link Frequency
blood 1
liver 1
skin 1
SLC17A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 5 100.00 Very High Very High Very High
tolerance 4 98.52 Very High Very High Very High
Bile 8 88.24 High High
Angina 2 83.36 Quite High
alcohol 8 82.92 Quite High
Pain 1 81.52 Quite High
nud 1 72.08 Quite High
pruritus 1 69.28 Quite High
headache 4 68.48 Quite High
Inflammation 10 52.32 Quite High
Disease Link Frequency Relevance Heat
Depression 5 100.00 Very High Very High Very High
Toxicity 39 99.32 Very High Very High Very High
Alcoholic Liver Cirrhosis 2 98.36 Very High Very High Very High
Liver Disease 8 97.36 Very High Very High Very High
Hepatotoxicity 33 93.84 High High
Jaundice 5 93.52 High High
Body Weight 8 91.44 High High
Hepatitis Virus Infection 2 91.32 High High
Hepatomegaly 2 90.80 High High
Hypersensitivity 6 88.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed an increased exercise tolerance after administration of metoprolol (P less than 0.001) and a significant reduction of ST segment depression for ST 0.8 (P less than 0.01) and AST (P less than 0.005) at the maximal commun work load attained by every patient in the metoprolol and placebo tests.
Negative_regulation (reduction) of AST associated with depression and tolerance
1) Confidence 0.42 Published 1979 Journal G Ital Cardiol Section Abstract Doc Link 261957 Disease Relevance 0.44 Pain Relevance 0.35
Without knowledge of the experimental groups, serum levels of albumin, bilirubin, ALT, AST, ?
Negative_regulation (levels) of AST
2) Confidence 0.41 Published 2007 Journal Comp Hepatol Section Body Doc Link PMC1920532 Disease Relevance 0.18 Pain Relevance 0.14
DMN-induced increases in serum AST, ALT and ALP levels were significantly suppressed by grape skin or seeds feeding.
Negative_regulation (suppressed) of AST in skin
3) Confidence 0.18 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2981719 Disease Relevance 0.43 Pain Relevance 0
Ninety percent of all subjects demonstrated a decrease in AST from baseline to week 8 (9 females and 9 males).
Negative_regulation (decrease) of AST
4) Confidence 0.09 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.13 Pain Relevance 0
A desirable change in these biomarkers (an increase in GSH and decreases in ALT, AST, AcP, AlkP and LPO) on drug administration suggests its potential in alleviating As toxicity in humans.


Negative_regulation (decreases) of AST associated with toxicity
5) Confidence 0.08 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.32 Pain Relevance 0
Silymarin 420 mg/day was also shown to improve indices of liver function [AST, ALT, gamma-glutamyl transferase and bilirubin] in patients with liver disease of various aetiology, including those exposed to toxic levels of toluene or xylene; however, it was largely ineffective in patients with viral hepatitis.
Negative_regulation (improve) of AST in liver associated with liver disease and hepatitis virus infection
6) Confidence 0.08 Published 2001 Journal BioDrugs Section Abstract Doc Link 11520257 Disease Relevance 1.00 Pain Relevance 0.14
In this study we found that AST decreased from baseline to week 4 and week 8 in both female and male subjects and these decreases attained significance in the female subjects.
Negative_regulation (decreased) of AST
7) Confidence 0.07 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2831093 Disease Relevance 0.05 Pain Relevance 0.08
Despite the introduction of rabbit ATG, the serum levels of ALT and AST continued to decrease gradually with time.
Negative_regulation (decrease) of AST
8) Confidence 0.06 Published 2007 Journal J Med Case Reports Section Body Doc Link PMC1920517 Disease Relevance 1.26 Pain Relevance 0
AST levels decreased from 8,581 to 42 IU/L within 11 days.
Negative_regulation (decreased) of AST
9) Confidence 0.05 Published 2006 Journal Clin Ther Section Body Doc Link 16861097 Disease Relevance 0.14 Pain Relevance 0
Immediate administration of continuous IV N-acetylcysteine 150 mg/kg for the first 90 minutes and then 50 mg/kg q4h for the next 3 days was followed by clinical improvement and a rapid decrease in AST and ALT.
Negative_regulation (decrease) of AST
10) Confidence 0.04 Published 2006 Journal Clin Ther Section Body Doc Link 16861097 Disease Relevance 0.14 Pain Relevance 0
Interestingly the activities of all toxicity denoting enzymes in blood, viz., AST, ALT, AcP and AlkP showed a steady decline and attained almost normal levels by 2 months time after drug administration (Fig. 3a–d).
Negative_regulation (decline) of AST in blood associated with toxicity
11) Confidence 0.04 Published 2005 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1297497 Disease Relevance 0.26 Pain Relevance 0
AST and ALT values were slightly diminished (100 and 170 U/L respectively), and alkaline phosphatase and GGT had decreased to 428 U/L and 170 U/L, respectively (Table 1).
Negative_regulation (diminished) of AST
12) Confidence 0.03 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2978230 Disease Relevance 1.15 Pain Relevance 0.04

General Comments

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