INT186912

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Context Info
Confidence 0.10
First Reported 2004
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 9
Disease Relevance 1.88
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

translation factor activity, nucleic acid binding (EIF1) translation (EIF1) response to stress (EIF1)
cytoplasm (EIF1)
Anatomy Link Frequency
A549 4
epithelial cells 1
respiratory 1
EIF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 98.84 Very High Very High Very High
Inflammatory response 18 87.20 High High
headache 9 66.80 Quite High
fifth nerve 9 38.00 Quite Low
Pain 9 34.92 Quite Low
Disease Link Frequency Relevance Heat
Toxicity 81 99.92 Very High Very High Very High
INFLAMMATION 54 98.84 Very High Very High Very High
Injury 9 80.60 Quite High
Pharyngitis 9 67.48 Quite High
Headache 9 66.80 Quite High
Heart Rate Under Development 9 66.40 Quite High
Flushing 9 65.72 Quite High
Cancer 63 17.28 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Figures 2B and 3B show the photochemical degradation of the initial ISO or BD with the formation of the first-generation photochemical products from the time of injection through the end of the exposure period.
Protein_catabolism (degradation) of ISO
1) Confidence 0.10 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
One concern when analyzing the results of the photochemical degradation products for both ISO and BD was the production of O3 and its known toxic health effects.
Protein_catabolism (degradation) of ISO
2) Confidence 0.10 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
Although respiratory health effects induced by some of the photochemical degradation products of ISO and BD are known, the toxicity of the entire photochemical reaction product mixture as it would occur in the atmosphere is unknown.
Protein_catabolism (degradation) of ISO in respiratory associated with toxicity
3) Confidence 0.10 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.68 Pain Relevance 0.11
Triplicate sets of A549 cells were separately exposed to ISO plus nitrogen oxides (NOx), BD plus NOx, photochemical degradation products of ISO plus NOx, or photochemical degradation products of BD plus NOx for 5 hr.
Protein_catabolism (degradation) of ISO in A549
4) Confidence 0.09 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.09 Pain Relevance 0.04
In this study, A549 cells were exposed to ISO, BD, or their photochemical degradation products.
Protein_catabolism (degradation) of ISO in A549
5) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.14 Pain Relevance 0.03
In this study, we interfaced human lung epithelial cells with a smog chamber, allowing us to assess the toxicity of ISO, BD, and their photochemical degradation products in parallel.
Protein_catabolism (degradation) of ISO in epithelial cells associated with toxicity
6) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.62 Pain Relevance 0.09
Triplicate sets of A549 cells were separately exposed to ISO plus nitrogen oxides (NOx), BD plus NOx, photochemical degradation products of ISO plus NOx, or photochemical degradation products of BD plus NOx for 5 hr.
Protein_catabolism (degradation) of ISO in A549
7) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0.08 Pain Relevance 0.04
The same experimental protocol was used to expose differentiated human bronchial cells to both ISO and BD photochemical degradation products.
Protein_catabolism (degradation) of ISO
8) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Body Doc Link PMC1247611 Disease Relevance 0 Pain Relevance 0
In this study, we determined the relative toxicity and inflammatory gene expression induced by exposure of A549 cells to BD, ISO, and their photochemical degradation products in the presence of nitric oxide.
Protein_catabolism (degradation) of ISO in A549 associated with toxicity and inflammation
9) Confidence 0.06 Published 2004 Journal Environ Health Perspect Section Abstract Doc Link PMC1247611 Disease Relevance 0.26 Pain Relevance 0.08

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